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General Review Article

口腔药物输送中的生物聚合物基质：现状和未来趋势

卷 27, 期 10, 2020

页: [1661 - 1669] 页: 9

弟呕挨: 10.2174/0929867325666181001114750

价格: $65

摘要

背景：本文对基于生物聚合物的底物，尤其是纤维素衍生物，在颊药物递送中的应用进行了综述。药物输送到颊粘膜具有肌肉不活动，丰富的血管形成和快速恢复的优点，但是由于分子大分子引起的生物利用度低，因此并非所有的药物都可以通过颊粘膜给药（例如大分子药物）。这种短缺激发了药物复合技术的迅速发展以及生物聚合物基质的相应使用。 方法：纤维素衍生物已被广泛开发用于药物制造以促进其递送。我们从事基于纤维素的药物复合技术的结构化研究。我们总结了特征性纤维素衍生物，这些衍生物已被用作颊递送系统中的生物相容性底物。在本文中，关于快速发展的纳米纤维素（NC）潜在用途的讨论也很值得注意。 结果：本观点论文中引用了78篇论文，其中大多数（65篇）发表于2010年晚些时候。47篇论文定义了颊药物递送系统及其基质。十五篇论文概述了纤维素衍生物的性质和应用。引入纳米纤维素作为纳米材料的前沿，有16篇论文强调了其在口腔给药药物复合中的适应性。 结论：该前瞻性论文的研究结果提出了纤维素衍生物（一种典型的生物聚合物）在颊药物输送系统中的潜在用途，以促进大分子药物的生物利用度。尤其提出了纳米纤维素（NC）作为一种创新的生物粘合剂/载体，用于在颊系统中控制药物的释放。

关键词: 颊部药物递送，生物聚合物，药物复合技术，纤维素衍生物，纳米纤维素（NC）。

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