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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

7-Azaindole Analogues as Bioactive Agents and Recent Results

Author(s): Neha Sharma* and Anurag

Volume 19, Issue 9, 2019

Page: [727 - 736] Pages: 10

DOI: 10.2174/1389557518666180928154004

Price: $65


Azaindoles have been accepted as important structures having various biological activities in medicinal chemistry in novel drug discovery. Various azaindole derivatives have been used commercially and newer analogues are synthesized continuously. As in literature, azaindole is a very potent moiety, its derivatives displayed a number of biological activities such as kinase inhibitors, cytotoxic agents, anti-angiogenic activity, CRTh2 receptor antagonists, melanin agonists, nicotine agonists, effectiveness in alzheimer disease, cytokinin analogs, Orai inhibitors in asthma and chemokine receptor- 2 (CCR2) antagonists. This review consists of biological activities of various azaindole analogs, reported so far, and their structure activity relations, along with future perspectives in this field.

Keywords: Azaindole, kinase inhibitor, orai inhibitor, cytotoxic agents, bioactive agents, anti-angiogenic activity.

Graphical Abstract
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