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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Decarboxylative Reactions: An Efficient and Versatile Strategy for Organic Transformations

Author(s): Xiao-hua Cai*, Mengzhi Yang and Bing Xie*

Volume 22, Issue 19, 2018

Page: [1906 - 1925] Pages: 20

DOI: 10.2174/1385272822666180905113105

Price: $65


Carboxylic acids are one type of the most common, readily available and structural diverse synthetic sources which gradually serve as versatile connection points in organic transformations. The decarboxylative reaction of carboxylic acids has attracted great attention in providing an efficient and powerful strategy for the construction of various valuable molecular skeletons. Over the past decades, a number of obvious and satisfactory achievements in the field have constantly emerged. The review mainly introduces recent advances on the decarboxylative reactions based on aliphatic, alkenylic or carbonic, aromatic and alkynylic acids as decarboxylative partners for the functionalization of C(sp3)-H, C(sp2)-H and C-heteroatom bonds since 2011.

Keywords: Carboxylic acid, decarboxylative reaction, coupling reaction, radical oxidative, functionalization, organic transformation.

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