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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents

Author(s): Maria Assunta Chiacchio , Daniela Iannazzo , Roberto Romeo, Salvatore V. Giofrè and Laura Legnani*

Volume 26, Issue 40, 2019

Page: [7166 - 7195] Pages: 30

DOI: 10.2174/0929867325666180904125400

Price: $65


Pyridine and pyrimidine derivatives have received great interest in recent pharmacological research, being effective in the treatment of various malignancies, such as myeloid leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs show a pyridine or pyrimidine core bearing different substituents. The aim of this review is to describe the most recent reports in this field, with reference to the newly discovered pyridineor pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding benzo-fused heterocyclic compounds, i.e. quinolines and quinazolines, are also reported.

Keywords: Nitrogenated heterocycles, pyridine, pyrimidine, biological activities, synthesis, molecular modeling.

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