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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Protein-derived Smart Materials for Medical Applications: Elastin-like Polypeptides

Author(s): Rui Lin*, Shanshan Wang and Wentian Liu

Volume 24 , Issue 26 , 2018

Page: [3008 - 3013] Pages: 6

DOI: 10.2174/1381612824666180903122432

Price: $65


A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin is collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics. The present paper reviews the physicochemical characteristics of ELPs and outlines a range of applications in biotechnology and medicine.

Keywords: Elastin-like polypeptides, inverse temperature phase transition, drug delivery, protein purification, tissue engineering, endoscopic submucosal injection solution.

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