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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

The Anticancer Effect of Sanguinarine: A Review

Author(s): Chenxing Fu, Guiping Guan* and Hongbing Wang*

Volume 24 , Issue 24 , 2018

Page: [2760 - 2764] Pages: 5

DOI: 10.2174/1381612824666180829100601

Price: $65


In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferative while reducing tumor cell antiangiogenic and anti-invasive properties. This paper describes various sanguinarine anti-cancer mechanisms, including inhibition of erroneously-activated signal transduction pathways, apoptosis, and tumor cell proliferation inhibition.

Keywords: Sanguinarine, anti-tumor, apoptosis, pathways, anti-inflammatory, cancer.

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