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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Models of Parkinson’s Disease with Special Emphasis on Drosophila melanogaster

Author(s): Ambreen Fatima, Smita Jyoti and Yasir Hasan Siddique*

Volume 17, Issue 10, 2018

Page: [757 - 766] Pages: 10

DOI: 10.2174/1871527317666180820164250

Price: $65


Background & Objective: Parkinson’s disease is the second most common neurodegenerative disorder affecting more than 1% of the population averaged 60 years of age. The majority of PD cases are sporadic and are probably caused by a combination of risk factors but 5-10% of the PD cases are familial. Due to the high degree of the gene, conservation in humans, mice and insects using an animal model system is a valuable approach to further elucidate the roles of the genes in PD.

Conclusion: The present review highlights the models used to study PD symptoms with special emphasis on Drosophila.

Keywords: Parkinson's disease, models, Drosophila, pathological, neurdegerative disorder, etiology.

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