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Current Proteomics


ISSN (Print): 1570-1646
ISSN (Online): 1875-6247

Review Article

Chaperone-Assisted Secretion in Bacteria: Protein and DNA Transport via Cell Membranes

Author(s): Lilian Goulart Schultz, Ljubica Tasic* and Juliana Fattori

Volume 16 , Issue 1 , 2019

Page: [54 - 63] Pages: 10

DOI: 10.2174/1570164615666180820154821

Price: $65


Bacteria use an impressive arsenal of secretion systems (1-7) to infect their host cells by exporting proteins, DNA and DNA-protein complexes via cell membranes. They use chaperone-usher pathways for host colonization as well. To be targeted for transportation across one (Gram-positive) or two membranes (Gram-negative), clients must be selected, guided and unfolded to pass through type 3 (T3SS) or type 4 (T4SS) secretion systems. For these processes, bacteria count on secretory chaperones that guide macromolecular transport via membranes. Moreover, if we know how these processes occur, we might be able to stop them and avoid bacterial infections. Thus, structural and functional characterizations of secretory chaperones become interesting, as these proteins are the perfect targets for blocking bacteria action. Therefore, this review focuses on a story of known mechanisms of chaperone- secretion assisted transport with special attention on virulence proteins and DNA transport in bacteria.

Keywords: Bacteria, secretion systems, secretory chaperones, chaperone-assisted secretion, protein, secretion.

Graphical Abstract
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