摘要
背景:老年人肠道微生物菌群失调可引起肠道漏肠,导致全身无反应炎症,促进神经炎症-阿尔茨海默病早期的相关病理机制。目的:微生物群的再平衡对肠道炎症和免疫激活有积极的影响。方法:对20例老年痴呆症患者(女性9例,男性11例,年龄76.7±9.6岁)进行常规实验室检查。平均最低心理状态评分为18.5±7.7分。对18例患者补充益生菌4周前后的免疫活化标志物&血清新蝶呤、色氨酸分解、肠道炎症标志物和粪便微生物组成进行了分析。结果:治疗后粪中zonulin浓度明显下降,而前粪肠杆菌含量较基线明显升高,差异有显着性(P<0.0 5)。同时,血清尿激酶浓度升高(p<0.05)。新蝶呤前后δ值与Kynurenine/色氨酸比值(Kyn/Trp)显著相关(P<0.05)。结论:阿尔茨海默病患者补充多种益生菌对肠道细菌组成和血清色氨酸代谢有影响。Kyn/Trp与新蝶呤浓度的相关性提示巨噬细胞和/或树突状细胞的激活。进一步的研究是有必要的,以剖析益生菌补充在阿尔茨海默氏病过程中的潜在后果。
关键词: 肠道微生物群,Faecalibacterium prausnitzii,益生菌,新蝶呤,脑肠轴,神经炎症,阿尔茨海默病,痴呆
Current Alzheimer Research
Title:Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study
Volume: 15 Issue: 12
关键词: 肠道微生物群,Faecalibacterium prausnitzii,益生菌,新蝶呤,脑肠轴,神经炎症,阿尔茨海默病,痴呆
摘要: Background: Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which may result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism in the early course of Alzheimer’s disease.
Objective: The rebalancing of the microbiome could benefically impact on gut inflammation and immune activation.
Methods: In this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 76.7 ± 9.6 years) with Alzheimer’s disease were investigated. The mean Mini Mental State Examination score was 18.5 ± 7.7. Biomarkers of immune activation – serum neopterin and tryptophan breakdown - as well as gut inflammation markers and microbiota composition in fecal specimens were analyzed in 18 patients before and after probiotic supplementation for 4 weeks.
Results: After treatment a decline of fecal zonulin concentrations and an increase in Faecalibacterium prausnitzii compared to baseline were observed. At the same time, serum kynurenine concentrations increased (p <0.05). Delta values (before - after) of neopterin and the kynurenine to tryptophan ratios (Kyn/Trp) correlated significantly (p <0.05).
Conclusion: Results show that the supplementation of Alzheimer’s disease patients with a multispecies probiotic influences gut bacteria composition as well as tryptophan metabolism in serum. The correlation between Kyn/Trp and neopterin concentrations points to the activation of macrophages and/or dendritic cells. Further studies are warranted to dissect the potential consequences of Probiotic supplementation in the course of Alzheimer’s disease.
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Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study, Current Alzheimer Research 2018; 15 (12) . https://dx.doi.org/10.2174/1389200219666180813144834
DOI https://dx.doi.org/10.2174/1389200219666180813144834 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
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Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
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