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Current Clinical Pharmacology


ISSN (Print): 1574-8847
ISSN (Online): 2212-3938

Review Article

Therapeutic Approach for Irritable Bowel Syndrome: Old and New Strategies

Author(s): Paolo Usai-Satta*, Massimo Bellini, Mariantonia Lai, Francesco Oppia and Francesco Cabras

Volume 13 , Issue 3 , 2018

Page: [164 - 172] Pages: 9

DOI: 10.2174/1574884713666180807143606

Price: $65


Background: Irritable bowel syndrome (IBS) is the most frequently diagnosed functional gastrointestinal disorder. It is characterised by abdominal pain, bloating and changes in bowel habits that can have a serious impact on the patient’s quality of life. Treatment strategies are based on the nature and severity of the symptoms, the degree of functional impairment of the bowel habits, and the presence of psychosocial disorders.

The purpose of this review is to update our current knowledge of therapeutic approach of this disorder.

Method: A literature search for IBS therapy was carried out using the online databases of Pubmed, Medline and Cochrane.

Results: An ideal treatment begins by explaining this condition and providing reassurance to the patients. There is limited evidence for the efficacy, and tolerability of the therapies currently available for the treatment of IBS. There is also a limited availability of pharmacological agents licensed specifically for the treatment of IBS subtypes, although new agents have been recently proposed to this goal. Furthermore, patients often associate their complaints with the ingestion of foods containing FODMAPs (fermentable oligo-di-monosaccharides, and polyols) and gluten derivates and a personalized diet can be proposed. However, more severe symptoms can be associated with greater levels of psychosocial problems and a psychological approach and antidepressant drugs can be needed.

Conclusion: The treatment of IBS remains focused on treating the patient’s predominant, or most troublesome, symptoms. New promising treatments have recently become available for the treatment of IBS but long term studies are still needed.

Keywords: Irritable bowel syndrome, constipation, pain, diarrhea, pharmacological agents, diet.

Graphical Abstract

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