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Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Research Article

The Effects of Tempeh Gembus, an Indonesian Fermented Food, on Lipid Profiles in Women with Hyperlipidemia

Author(s): Diana Nur Afifah*, Nida Nabilah, Galuh Tamarasani Supraba, Syafira Noor Pratiwi, Nuryanto and Mohammad Sulchan

Volume 16, Issue 1, 2020

Page: [56 - 64] Pages: 9

DOI: 10.2174/1573401314666180807112549

Open Access Journals Promotions 2
Abstract

Background: Hyperlipidemia is the major precursor of lipid-related diseases. Consumption of high fiber foods may decrease lipid profiles. The fiber content in tempeh gembus is three times higher than regular tempeh.

Objective: This study was conducted to investigate the effect of tempeh gembus on lipid profiles in women with hyperlipidemia.

Methods: This research used the quasi-experimental design with nonequivalent control group design. Subjects were 41 women with hyperlipidemia, classified into 3 groups: control group, treatment group 1 given 103 g/day tempeh gembus, and treatment group 2 given 206 g/day tempeh gembus for 14 days. All of the groups received nutrition education. Total cholesterol and HDL-C were determined by CHOD-PAP method, triglyceride determined by enzymatic GPO-PAP method after subjects had been fasting for approximately 10 hours. LDL-C was calculated by Friedewald equation.

Results: These results showed that consumption of tempeh gembus 103 g/day and 206 g/day decreased LDL-C 27.9% and 30.9% as well as decreased total cholesterol 17.7% and 19.8% respectively. However, HDL-C increased 3.91% and 8.79% and triglyceride increased 2.3% and 3.1%. Tempeh gembus given 206 g/day was more effective to decrease total cholesterol and LDL-C than 103 g/day.

Conclusion: Increasing tempeh gembus consumption in women with hyperlipidemia should be addressed to decrease LDL-C and total cholesterol.

Keywords: Fiber, HDL-C, hyperlipidemia, LDL-C, Tempeh Gembus, total cholesterol, triglyceride.

Graphical Abstract
[1]
American Heart Association. Heart disease and stroke statistics – at-a-glance heart disease, stroke and other cardiovascular diseases heart disease, stroke and cardiovascular disease risk factors 2015; 7-10.
[2]
Profil kesehatan dasar. RISKESDAS 2013; 161-4.
[3]
Semarang DKK. Profil kesehatan kota semarang 2015; 55-9.
[4]
Pujol TJ, Tucker JE, Barnes JT. Diseases of the cardiovascular system Nutrition Therapy and Pathophysiology United States of America. Wadsworth 2011; pp. 298-315.
[5]
Onwe PE, Folawiyo MA, Anyigor Ogah CS, Umahi G. Okorocha, Afoke AO. Hyperlipidemia: etiology and possible control. IOSR-JDMS 2015; 14: 93-100.
[6]
Nelson RH. Hyperlipidemia as a risk factor for cardiovascular disease. Prim Care 2013; 40(1): 195-211.
[http://dx.doi.org/10.1016/j.pop.2012.11.003] [PMID: 23402469]
[7]
Khot UN, Khot MB, Bajzer CT, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003; 290(7): 898-904.
[http://dx.doi.org/10.1001/jama.290.7.898] [PMID: 12928466]
[8]
Shamal L, Lurix E, Shen M, et al. Association of body mass index and lipid profiles: evaluation of a broad spectrum of BMI patients including the morbidly obese. J Surg 2011; 21(1): 42-7.
[9]
Bays HE, Toth PP, Kris-Etherton PM, et al. Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association. J Clin Lipidol 2013; 7(4): 304-83.
[http://dx.doi.org/10.1016/j.jacl.2013.04.001] [PMID: 23890517]
[10]
Arnett DK, Jacobs DR Jr, Luepker RV, Blackburn H, Armstrong C, Claas SA. Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use: The Minnesota Heart Survey, 1980-1982 to 2000-2002. Circulation 2005; 112(25): 3884-91.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.105.549857] [PMID: 16344385]
[11]
Teixeira SR, Potter SM, Weigel R, Hannum S, Erdman JW Jr, Hasler CM. Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am J Clin Nutr 2000; 71(5): 1077-84.
[http://dx.doi.org/10.1093/ajcn/71.5.1077] [PMID: 10799368]
[12]
Le D, Alvin G, Vitoo L, Michelle AW. Prevalence and risk factors of hypercholesterolemia among thai men and women receivig health examinations. J Trop Med Public Health 2006; 37(5): 1005-14.
[13]
Simonetti MS, Damiani F, Gabrielli L, et al. Characterization of Triacylglycerols in Arbutus unedo L. Seeds. Ital J Food Sci 2008; 20(1): 49-56.
[14]
Kelly RB. Diet and exercise in the management of hyperlipidemia. Am Fam Physician 2010; 81(9): 1097-102.
[PMID: 20433126]
[15]
West SG, Hilpert KF, Juturu V, et al. Effects of including soy protein in a blood cholesterol-lowering diet on markers of cardiac risk in men and in postmenopausal women with and without hormone replacement therapy. J Womens Health (Larchmt) 2005; 14(3): 253-62.
[http://dx.doi.org/10.1089/jwh.2005.14.253] [PMID: 15857272]
[16]
Astuti M, Meliala A, Dalais FS, Wahlqvist ML. Tempe, a nutritious and healthy food from Indonesia. Asia Pac J Clin Nutr 2000; 9(4): 322-5.
[http://dx.doi.org/10.1046/j.1440-6047.2000.00176.x] [PMID: 24394511]
[17]
O’Toole DK. Characteristics and use of okara, the soybean residue from soy milk production--a review. J Agric Food Chem 1999; 47(2): 363-71.
[http://dx.doi.org/10.1021/jf980754l] [PMID: 10563901]
[18]
Kusumaningsih T, Ariani SR, Agustina W. Profil kandungan daidzein dan genistein pada tempe gembus selama proses fermentasi. J Alchemy 2006; pp. 45-53.
[19]
Afifah DN, Sulchan M, Syah D. Yanti, Suhartono MT. Isolation and identification of fibrinolytic protease-producing microorganisms from Red Oncom and Gembus, Indonesian fermented soybean cakes. Malays J Microbiol 2014; 10(4): 273-9.
[20]
Afifah DN, Sulchan M, Syah D. Yanti, Suhartono MT, Kim JH. Purification and characterization of a fibrinolytic enzyme from Bacillus pumilus 2.g isolated from gembus, an Indonesian fermented food. Prev Nutr Food Sci 2014; 19(3): 213-9.
[http://dx.doi.org/10.3746/pnf.2014.19.3.213] [PMID: 25320719]
[21]
Afifah DN, Rustanti N, Anjani G, Syah D. Yanti, Suhartono MT. Proteomics study of extracellular fibrinolytic proteases from Bacillus licheniformis RO3 and Bacillus pumilus 2.g isolated from Indonesian fermented food. IOP Conf Ser: Earth Environ Sci 2017; 55-012025.
[22]
Kurniasari R, Sulchan M, Afifah DN, Anjani G, Rustanti N. Influence variation of tempe gembus (an Indonesian fermented food) on homocysteine and malondialdehyde of rats fed an atherogenic diet. Rom J Diabetes Nutr Metab Dis 2017; 24(3): 203-11.
[http://dx.doi.org/10.1515/rjdnmd-2017-0026]
[23]
Dewi PK, Afifah DN, Rustanti N, Sulchan M, Anjani G. The effect of tempeh gembus variations to serum levels of high sensitivity creactive protein (hscrp) and serum levels of fibrinogen of sparague dawley rats with atherogenic diet. Rom J Diabetes Nutr Metab Dis 2018; 25(1): 091-7.
[24]
Noviana A, Dieny FF, Rustanti N, Anjani G, Afifah DN. Antimicrobial activity of tempeh gembus hydrolyzate. IOP Conf Ser: Earth Environ Sci 2018; 116: 012044.
[25]
Damanik RNS, Pratiwi DYW, Widyastuti N, Rustanti N, Anjani G, Afifah DN. Nutritional composition changes during tempeh gembus processing. IOP Conf Ser: Earth Environ Sci 116: 012026.
[http://dx.doi.org/10.1088/1755-1315/116/1/012026]
[26]
Sulchan M, Rukmi MGI. Effect of tempe gembus on cholesterol profile in hyperlipidemic rats. Ind J Med 2007; 16: 205-12.
[http://dx.doi.org/10.13181/mji.v16i4.281]
[27]
van Bennekum AM, Nguyen DV, Schulthess G, Hauser H, Phillips MC. Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters. Br J Nutr 2005; 94(3): 331-7.
[http://dx.doi.org/10.1079/BJN20051498] [PMID: 16176602]
[28]
Rosell MS, Appleby PN, Spencer EA, Key TJ. Soy intake and blood cholesterol concentrations: a cross-sectional study of 1033 pre- and postmenopausal women in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2004; 80(5): 1391-6.
[http://dx.doi.org/10.1093/ajcn/80.5.1391] [PMID: 15531691]
[29]
Mesomya W, Pakpeankitvatana V, Komindr S, et al. Effects of health food from cereal and nata de coco on serum lipids in human. Songklanakarin J Sci Technol 2006; 28(Suppl. 1): 24-8.
[30]
Thomas F, Bean K, Pannier B, Oppert JM, Guize L, Benetos A. Cardiovascular mortality in overweight subjects: the key role of associated risk factors. Hypertension 2005; 46(4): 654-9.
[http://dx.doi.org/10.1161/01.HYP.0000184282.51550.00] [PMID: 16157786]
[31]
Grabauskas V, Miseviciene I, Klumbiene J, et al. Prevalence of dyslipidemias among Lithuanian rural population (CINDI program). Medicina (Kaunas) 2003; 39(12): 1215-22.
[PMID: 14704511]
[32]
Krummel DA. Medical nutrition therapy for cardiovascular disease krause’s food, nutrition and diet therapy. 12th ed. Saunders USA. 2008; pp. 837-42.
[33]
Jahari AB, Sumarno I. Epidemiologi konsumsi serat di Indonesia. Gizi Indonesia 2001; 25: 37-56.
[34]
Fernandez ML, West KL. Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr 2005; 135(9): 2075-8.
[http://dx.doi.org/10.1093/jn/135.9.2075] [PMID: 16140878]
[35]
Hu X, Gao J, Zhang Q, et al. Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial. Mol Nutr Food Res 2013; 57(12): 2147-54.
[http://dx.doi.org/10.1002/mnfr.201300159] [PMID: 23881774]
[36]
Kim HS, Yu OK, Byun MS, Cha YS. Okara, a soybean by-product, prevents high fat diet-induced obesity and improves serum lipid profiles in C57BL/6J mice. Food Sci Biotechnol 2016; 25(2): 607-13.
[http://dx.doi.org/10.1007/s10068-016-0085-8] [PMID: 30263313]
[37]
Clarkson TB. Soy, soy phytoestrogens and cardiovascular disease. J Nutr 2002; 132(3): 566S-9S.
[http://dx.doi.org/10.1093/jn/132.3.566S] [PMID: 11880594]
[38]
Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999; 69(1): 30-42.
[http://dx.doi.org/10.1093/ajcn/69.1.30] [PMID: 9925120]
[39]
Sedaghat A, Hajiej S, Fatemeh H, Seyed PP, Alireza J, Seyed ML. The effect of soy nuts on glycemic control, lipid profile and insuline-resistance in type 2 diabetic patients. J Endocrinol Metab Dis 2015; 5: 1-7.
[40]
Babio N, Balanza R, Basulto J, Bulló M, Salas-Salvadó J. Dietary fibre: influence on body weight, glycemic control and plasma cholesterol profile. Nutr Hosp 2010; 25(3): 327-40.
[PMID: 20593113]
[41]
Anderson JW, Allgood LD, Lawrence A, et al. Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 2000; 71(2): 472-9.
[http://dx.doi.org/10.1093/ajcn/71.2.472] [PMID: 10648260]
[42]
Thompson PD, Rader DJ. Does exercise increase HDL cholesterol in those who need it the most? Arterioscler Thromb Vasc Biol 2001; 21(7): 1097-8.
[http://dx.doi.org/10.1161/hq0701.092147] [PMID: 11451735]
[43]
Torres N, Torre-Villalvazo I, Tovar AR. Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders. J Nutr Biochem 2006; 17(6): 365-73.
[http://dx.doi.org/10.1016/j.jnutbio.2005.11.005] [PMID: 16481155]
[44]
Greany KA, Nettleton JA, Wangen KE, Thomas W, Kurzer MS. Human nutrition and metabolism probiotic consumption does not enhance the cholesterol-lowering effect of soy in postmenopausal women. J Hum Nutr Metab 2004; 3: 3277-83.
[45]
Sanjukta S, Rai AK. Production of bioactive peptides during soybean fermentation and their potential health benefits. Trends Food Sci Technol 2016; 50: 1-0.
[http://dx.doi.org/10.1016/j.tifs.2016.01.010]
[46]
Cho SJ, Juillerat MA, Lee CH. Cholesterol lowering mechanism of soybean protein hydrolysate. J Agric Food Chem 2007; 55(26): 10599-604.
[http://dx.doi.org/10.1021/jf071903f] [PMID: 18052124]
[47]
Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr 2005; 81(2): 397-408.
[http://dx.doi.org/10.1093/ajcn.81.2.397] [PMID: 15699227]
[48]
Agustina W. Profil kandungan daidzein dan genistein pada tempe gembus selama proses fermentasi 2001; 1-66.
[49]
Parks EJ. Effect of dietary carbohydrate on triglyceride metabolism in humans. J Nutr 2001; 131(10): 2772S-4S.
[http://dx.doi.org/10.1093/jn/131.10.2772S] [PMID: 11584104]
[50]
IPAQ Research Committee. Guidelines for data processing and analysis of the International Physical Activity Questionnaire (IPAQ) short and long forms 2005.
[51]
WS,Mokdad AH. Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med 2009; 169(6): 572-8.
[http://dx.doi.org/10.1001/archinternmed.2008.599] [PMID: 19307519]
[52]
Parnell JA, Reimer RA. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 2009; 89(6): 1751-9.
[http://dx.doi.org/10.3945/ajcn.2009.27465] [PMID: 19386741]
[53]
Eltayeb T, Abdelmotal TM, Hisam MA. Serum lipid profile of obese and overweight sudanese over 60 years. Int J Adv Pharma Biol Chem 2014; 3: 876-1.
[54]
Finelli C, Crispino P, Gioia S, et al. The improvement of large High-Density Lipoprotein (HDL) particle levels, and presumably HDL metabolism, depend on effects of low-carbohydrate diet and weight loss. EXCLI J 2016; 15: 166-76.
[http://dx.doi.org/10.17179/excli2015-642] [PMID: 27103896]
[55]
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001; 285(19): 2486-97.
[http://dx.doi.org/10.1001/jama.285.19.2486] [PMID: 11368702]
[56]
Marlett JA, McBurney MI, Slavin JL. American Dietetic Association. Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 2002; 102(7): 993-1000.
[http://dx.doi.org/10.1016/S0002-8223(02)90228-2] [PMID: 12146567]
[57]
Park SH, Lee KS, Park HY. Dietary carbohydrate intake is associated with cardiovascular disease risk in Korean: analysis of the third Korea National Health and Nutrition Examination Survey (KNHANES III). Int J Cardiol 2010; 139(3): 234-40.
[http://dx.doi.org/10.1016/j.ijcard.2008.10.011] [PMID: 19013653]
[58]
Mooradian AD, Haas MJ. The effect of nutritional supplements on serum high-density lipoprotein cholesterol and apolipoprotein A-I. Am J Cardiovasc Drugs 2014; 14(4): 253-74.
[http://dx.doi.org/10.1007/s40256-014-0068-1] [PMID: 24604774]
[59]
Santos FL, Esteves SS, da Costa Pereira A, Yancy WS Jr, Nunes JP. Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors. Obes Rev 2012; 13(11): 1048-66.
[http://dx.doi.org/10.1111/j.1467-789X.2012.01021.x] [PMID: 22905670]
[60]
Ruth MR, Port AM, Shah M, et al. Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects. Metabolism 2013; 62(12): 1779-87.
[http://dx.doi.org/10.1016/j.metabol.2013.07.006] [PMID: 24075505]
[61]
Rodwell V, Bender D, Botham KM, Kennelly PJ, Weil PA. Harpers illustrated biochemistry. 30th ed. McGraw Hill Professional USA. 2015.
[62]
Ahmed HM, Blaha MJ, Nasir K, Rivera JJ, Blumenthal RS. Effects of physical activity on cardiovascular disease. Am J Cardiol 2012; 109(2): 288-95.
[http://dx.doi.org/10.1016/j.amjcard.2011.08.042] [PMID: 22011559]

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