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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Research Article

Eyelid Dermatitis and Contact Sensitization to Nickel: Results from an Italian Multi-Centric Observational Study

Author(s): Alessandro Borghi*, Monica Corazza, Elisa Maietti, Cataldo Patruno, Maddalena Napolitano, Donatella Schena, Maria Letizia Musumeci, Giuseppe Micali, Thea Magrone, Paolo Romita and Caterina Foti

Volume 19, Issue 1, 2019

Page: [38 - 45] Pages: 8

DOI: 10.2174/1871530318666180731114418

Price: $65


Background: Due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and nickel contained in make-ups remains controversial.

Objective: The study aimed to assess the association between nickel allergy, the use of pigmented makeup products and self-reported eyelid dermatitis.

Method: This multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients) and 103 women without intolerance to metals (controls). We recorded: demographics, atopy, use of pigmented eye cosmetics (mascara, eyeshadow, eyeliner, eyebrow pencil), and previous eyelid dermatitis. Among the patients, any co-sensitization to cosmetics or metals was recorded.

Results: 87.3% of the patients and 91.3% of the controls reported their use of eye make-up; 44.9% and 52.4%, respectively, reported previous episodes of eyelid dermatitis, without significant differences. The occurrence of eyelid dermatitis was significantly associated with the use of eye make-up products, both in general and considering each product separately. Age, atopy, or co-sensitization to other metals or cosmetics did not affect the occurrence of eyelid dermatitis.

Conclusion: Nickel allergy should not be considered the main risk factor for eyelid dermatitis. The use of pigmented eye make-up may be a triggering factor for eyelid dermatitis, probably due to an irritant action.

Keywords: Eyelid dermatitis, nickel allergy, make-up products, allergic contact dermatitis, cosmetics, irritant contact dermatitis.

Graphical Abstract
Wolf, R.; Orion, E.; Tüzün, Y. Periorbital (eyelid) dermatides. Clin. Dermatol., 2014, 32, 131-140.
Temesvári, E.; Pónyai, G.; Németh, I.; Hidvégi, B.; Sas, A.; Kárpáti, S. Periocular dermatitis: A report of 401 patients. J. Eur. Acad. Dermatol. Venereol., 2009, 23, 124-128.
Guin, J. Eyelid dermatitis: A report of 215 patients. Contact Dermat., 2004, 50, 87-90.
Oh, J.E.; Lee, H.J.; Choi, Y.W.; Choi, H.Y.; Byun, J.Y. Metal allergy in eyelid dermatitis and the evaluation of metal contents in eye shadows. J. Eur. Acad. Dermatol. Venereol., 2016, 30, 1518-1521.
Thyssen, J.P.; Linneberg, A.; Menné, T.; Nielsen, N.H.; Johansen, J.D. No association between nickel allergy and reporting cosmetic dermatitis from mascara or eye shadow: A cross-sectional general population study. J. Eur. Acad. Dermatol. Venereol., 2010, 24, 722-725.
Sainio, E.L.; Jolanki, R.; Hakala, E.; Kanerva, L. Metals and arsenic in eye shadows. Contact Dermat., 2000, 42, 5-10.
Amin, K.A.; Belsito, D.V. The aetiology of eyelid dermatitis: A 10-year retrospective analysis. Contact Dermat., 2006, 55, 280-285.
Feser, A.; Plaza, T.; Vogelgsang, L.; Mahler, V. Periorbital dermatitis-a recalcitrant disease: Causes and differential diagnoses. Br. J. Dermatol., 2008, 159, 858-863.
Herbst, R.A.; Uter, W.; Pirker, C.; Geier, J.; Frosch, P.J. Allergic and non-allergic periorbital dermatitis: Patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Contact Dermat., 2004, 51, 13-19.
Landeck, L.; Schalock, P.C.; Baden, L.A.; Gonzalez, E. Periorbital contact sensitization. Am. J. Ophthalmol., 2010, 150, e362.
Johansen, J.D.; Aalto-Korte, K.; Agner, T.; Andersen, K.E.; Bircher, A.; Bruze, M.; Cannavó, A.; Giménez-Arnau, A.; Gonçalo, M.; Goossens, A.; John, S.M.; Lidén, C.; Lindberg, M.; Mahler, V.; Matura, M.; Rustemeyer, T.; Serup, J.; Spiewak, R.; Thyssen, J.P.; Vigan, M.; White, I.R.; Wilkinson, M.; Uter, W. European society of contact dermatitis guideline for diagnostic patch testing - Recommendations on best practice. Contact Dermat., 2015, 3, 195-221.
Cheong, S.H.; Choi, Y.W.; Choi, H.Y.; Byun, J.Y. Nickel and cobalt release from jewellery and metal clothing items in Korea. Contact Dermat., 2014, 70, 11-18.
Travassos, A.R.; Bruze, M.; Dahlin, J.; Goossens, A. Allergic contact dermatitis caused by nickel in a green eye pencil. Contact Dermat., 2011, 65, 307-308.
Hong, Y.J.; Choi, H.Y.; Kim, K.J. Y.L.; Ga, D.W.; Kim, S.J.; Kim, S.C.; Kim, Y.S.; Ro, K.C.; Moon, M.Y.; Park, S.W.; Son, J.H.; Shin, J.M.; Yang, H.C. Eun, M.G.; Lee, C.H.; Lee, C.K. Hong. True test in patients with contact dermatitis: A multicenter study. Korean J. Dermatol., 2011, 49, 661-669.
Herro, E.M.; Elsaie, M.L.; Nijhawan, R.I.; Jacob, S.E. Recommendations for a screening series for allergic contact eyelid dermatitis. Dermatitis, 2012, 23, 17-21.
Corazza, M.; Baldo, F.; Pagnoni, A.; Miscioscia, R.; Virgili, A. Measurement of nickel, cobalt and chromium in toy make-up by atomic absorption spectroscopy. Acta Derm. Venereol., 2009, 89, 130-133.
Volpe, M.G.; Nazzaro, M.; Coppola, R.; Rapuano, E.; Aquino, R.P. Determination and assessments of selected heavy metals in eye shadow cosmetics from China, Italy, and USA. Microchem. J., 2012, 101, 65-69.
Adams, R.M.; Maibach, H.I. A five-year study of cosmetic reactions. J. Am. Acad. Dermatol., 1985, 13, 1062-1069.

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