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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

The Role of Neuroimaging in the Diagnosis and Treatment of Depressive Disorder: A Recent Review

Author(s): Tianbin Song, Xiaowei Han, Lei Du, Jing Che, Jing Liu, Sumin Shi, Chao Fu, Wenwen Gao, Jie Lu* and Guolin Ma*

Volume 24 , Issue 22 , 2018

Page: [2515 - 2523] Pages: 9

DOI: 10.2174/1381612824666180727111142

Price: $65


Depression is a mental disorder with serious negative health outcomes. Its main clinical manifestations are depressed mood, slow thinking, loss of interest, and lack of energy. The rising incidence of depression has a major impact on patients and their families and imposes a substantial burden on society. With the rapid development of imaging technology in recent years, researchers have studied depression from different perspectives, including molecular, functional, and structural imaging. Many studies have revealed changes in structure, function, and metabolism in various brain regions in patients with depressive disorder. In this review, we summarize relevant studies of depression, including investigations using structural magnetic resonance imaging (MRI), functional MRI (task-state fMRI and resting-state fMRI), diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS), brain network and molecular imaging (positron emission tomography [PET] and single photon emission computed tomography [SPECT]), which have contributed to our understanding of the etiology, neuropathology, and pathogenesis of depressive disorder.

Keywords: Depressive disorder, neuroimaging, magnetic resonance imaging, cerebral blood flow, diffusion tensor imaging, positron emission tomography, single photon emission computed tomography.

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