Abstract
Atherothrombosis-related diseases are one of the world’s leading causes of mortality, and thus the search for new therapeutic approaches in this area remains a very urgent task. Modern pharmacogenomic technologies make it possible to obtain valuable data on disease pathogenesis and optimal therapeutic approaches. One promising research direction is the study of the thromboxane A2 - thromboxane A synthase - thromboxane A2 receptor axis. This review summarizes the recent evidence and suggests that systematic works in this area are creating new and promising opportunities in the treatment of patients with cardiovascular diseases.
Keywords: Inhibitors of thromboxane A2-synthase, pharmacogenetics, thromboxane A synthase, thromboxane, cardiovascular diseases, prostaglandins.
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title:Thromboxane A Synthase: A New Target for the Treatment of Cardiovascular Diseases
Volume: 16 Issue: 2
Author(s): Dinara F. Mesitskaya, Abram L. Syrkin, Marina G. Aksenova, Yong Zhang, Andrey A. Zamyatnin Jr.*Philipp Y. Kopylov*
Affiliation:
- Sechenov First Moscow State Medical University, Moscow,Russian Federation
- Sechenov First Moscow State Medical University, Moscow,Russian Federation
Keywords: Inhibitors of thromboxane A2-synthase, pharmacogenetics, thromboxane A synthase, thromboxane, cardiovascular diseases, prostaglandins.
Abstract: Atherothrombosis-related diseases are one of the world’s leading causes of mortality, and thus the search for new therapeutic approaches in this area remains a very urgent task. Modern pharmacogenomic technologies make it possible to obtain valuable data on disease pathogenesis and optimal therapeutic approaches. One promising research direction is the study of the thromboxane A2 - thromboxane A synthase - thromboxane A2 receptor axis. This review summarizes the recent evidence and suggests that systematic works in this area are creating new and promising opportunities in the treatment of patients with cardiovascular diseases.
Export Options
About this article
Cite this article as:
Mesitskaya F. Dinara , Syrkin L. Abram , Aksenova G. Marina , Zhang Yong , Zamyatnin Jr. A. Andrey *, Kopylov Y. Philipp *, Thromboxane A Synthase: A New Target for the Treatment of Cardiovascular Diseases, Cardiovascular & Hematological Agents in Medicinal Chemistry 2018; 16 (2) . https://dx.doi.org/10.2174/1871525716666180724115132
DOI https://dx.doi.org/10.2174/1871525716666180724115132 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
Call for Papers in Thematic Issues
Medicinal Plants with Beneficial Properties on Diabetes and Hypertension
Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Overview of Systems Biology and Omics Technologies
Current Medicinal Chemistry Activity Pacing Education for People with Osteoarthritis: A Systematic Review of the Current Evidence-base
Current Rheumatology Reviews Highly Active Antiretroviral Therapy and Cardiovascular Complications in HIV-Infected Patients
Current Pharmaceutical Design The Paradox of Caffeine-Zolpidem Interaction: A Network Analysis
Current Drug Targets Matrix Metalloproteinase-2 and Epidermal Growth Factor are Decreased in Platelets of Alzheimer Patients
Current Alzheimer Research C-Reactive Protein and Hypertension: Is there A Causal Relationship?
Current Pharmaceutical Design Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry
Current Neuropharmacology Gender-specific, Lifestyle-related Factors and 10-year Cardiovascular Disease Risk; the ATTICA and GREECS Cohort Studies
Current Vascular Pharmacology Serpins for Diagnosis and Therapy in Cancer
Cardiovascular & Hematological Disorders-Drug Targets Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration
Current Stem Cell Research & Therapy Inducible Nitric Oxide Synthase as a Possible Target in Hypertension
Current Drug Targets Medicinal Chemistry and Therapeutic Potential of Agonists, Antagonists and Allosteric Modulators of A1 Adenosine Receptor: Current Status and Perspectives
Current Pharmaceutical Design The Effect of Lead Exposure on Selected Blood Inflammatory Biomarkers in Guinea pigs
Cardiovascular & Hematological Disorders-Drug Targets Simultaneous Determination of Telmisartan and Pitavastatin Calcium in Intestinal Perfusate by HPLC: Application to Intestinal Absorption Interaction Study
Pharmaceutical Nanotechnology Recent Advances Toward Improving the Bioavailability of Neuronal Nitric Oxide Synthase Inhibitors
Current Topics in Medicinal Chemistry Flavonoids from Stem and Leaf of <i>Scutellaria Baicalensis</i> Georgi Inhibit the Phosphorylation on Multi-sites of Tau Protein Induced by Okadaic Acid and the Regulative Mechanism of Protein Kinases in Rats
Combinatorial Chemistry & High Throughput Screening Cell Sheet Technology for Heart Failure
Current Pharmaceutical Biotechnology Insulin Resistance and the Renin-Angiotensin-Aldosterone System in Metabolic Syndrome and Obesity-Related Hypertension
Current Hypertension Reviews Cardiovascular and Pulmonary Manifestations of Systemic Lupus Erythematosus
Current Rheumatology Reviews Effects of Anesthetics on Mitochondrial Signaling and Function
Current Drug Safety