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Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Review Article

Therapeutic Potential of Citronella Essential Oil: A Review

Author(s): Ruchi Sharma, Rekha Rao*, Sunil Kumar, Sheefali Mahant and Sarita Khatkar

Volume 16, Issue 4, 2019

Page: [330 - 339] Pages: 10

DOI: 10.2174/1570163815666180718095041

Price: $65

Abstract

Mosquito-borne diseases such as malaria, filariasis, chikunguniya, yellow fever, dengue and Japanese encephalitis are the major cause of remarkable morbidity and mortality in livestock and humans worldwide. Since ancient times, aromatic plants are used for their medicinal value. Essential oils derived from these plants may be used as effective alternatives/adjuvants in pharmaceuticals, biomedical, cosmetic, food, veterinary and agriculture applications. These oils have also gained popularity and interest for prevention and treatment of various disorders. However, several reports on adverse effects including skin eruption, contact artricaria or toxic encephalopathy in children are available for synthetic repellent in the literature. Thus, natural insect repellents like essential oils have been explored recently as an alternative. One such essential oil studied widely, is citronella oil, extracted mainly from Cymbopogon nardus. This essential oil has exhibited good efficacy against mosquitoes. It is a mixture of components including citronellal, citronellol, geraniol as major constituents contributing to various activities (antimicrobial, anthelmintic, antioxidant, anticonvulsant antitrypanosomal and wound healing), besides mosquito repellent action. Citronella essential oil is registered in US EPA (Environmental protection agency) as insect repellent due to its high efficacy, low toxicity and customer satisfaction. However, poor stability in the presence of air and high temperature limits its practical applications. Since specific knowledge on properties and chemical composition of oil is fundamental for its effective application, the present review compiles and discusses biological properties of citronella oil. It also sheds light on various formulations and applications of this essential oil.

Keywords: Essential oils, citronella oil, mosquito repellant, safety, toxicity, formulations.

Graphical Abstract
[1]
Pan SY, Zhou SF, Gao SH, et al. New perspectives on how to discover drugs from herbal medicines: CAM’s outstanding contribution to modern therapeutics. J Evid Based Complementary Altern Med 2013; 25: 2013.
[2]
Maridass M, De Britto AJ. Origins of plant derived medicines. Ethnobot Leaflets 2008; 2008(1): 44.
[3]
Lahlou M. The success of natural products in drug discovery. Pharmacology & Pharmacy 2013; 4(3A): 17.
[4]
James EF, Reynolds F. Martindale: The extra pharmacopoeia. Royal Pharmaceutical Society, London 1996. 1738.
[5]
Lis‐Balchin M, Deans SG. Bioactivity of selected plant essential oils against Listeria monocytogenes. J Appl Microbiol 1997; 82(6): 759-62.
[6]
Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils-a review. Food Chem Toxicol 2008; 46(2): 446-75.
[7]
Lei J, Zhou J. A marine natural product database. J Chem Inf Comput Sci 2002; 42(3): 742-8.
[8]
Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999; 86(6): 985-90.
[9]
Burt S. Essential oils: Their antibacterial properties and potential applications in foods-a review. Int J Food Microbiol 2004; 94(3): 223-53.
[10]
Wijesekera RO, Jayewardene AL, Fonseka BD. Varietal differences in the constituents of citronella oil. Phytochemistry 1973; 12(11): 2697-704.
[11]
Cheng SS, Liu JY, Tsai KH, Chen WJ, Chang ST. Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. J Agric Food Chem 2004; 52(14): 4395-400.
[12]
Wany A, Jha S, Nigam VK, Pandey DM. Chemical analysis and therapeutic uses of citronella oil from Cymbopogon winterianus: a short review. Int J Adv Res 2013; 1(6): 504-21.
[13]
Chemical Product. Available from: Chemical book.com
[14]
Nakahara K, Alzoreky NS, Yoshihashi T, Nguyen HT, Trakoontivakorn G. Chemical composition and antifungal activity of essential oil from Cymbopogon nardus (citronella grass). JARQ 2013; 37(4): 249-52.
[15]
Wei LS, Wee W. Chemical composition and antimicrobial activity of Cymbopogon nardus citronella essential oil against systemic bacteria of aquatic animals. Iran J Microbiol 2013; 5(2): 147-52.
[16]
Nerio LS, Olivero-Verbel J, Stashenko E. Repellent activity of essential oils: A review. Bioresour Technol 2010; 101(1): 372-8.
[17]
Citronella candle. U.S. Patent 2,323,804, 1943.
[18]
Robert Y. inventor;Scm Corp, assignee. Process for reconstituting natural citronella oil. United states patent US 3,579,468, 1971.
[19]
Hautmann H. inventor. Insect repellent. United States patent US 4,164,561, 1979.
[20]
Thielen P, Thielen CA. Herbal repellent composition. United States patent US 4,671,960, 1987.
[21]
Sherwood K, Sherwood F. Repellent composition containing natural oils of citronella, cedar and wintergreen and use thereof. United States patent US 5, 106, 622, 1992.
[22]
Magdassi S, Mumcuoglu K, Bach U. Method of preparing natural-oil-containing emulsions and microcapsules and its uses. United States patent US 5,518,736, 1996.
[23]
Blum M, Roitberg M. Natural insect repellent formula and method of making same. United States patent US 5,885,600, 1999.
[24]
Ryan RE, Morris S. Barrier Biotech Limited, assignee. Herbicide. United States patent US 6,472,351, 2002.
[25]
Shan LD, Xiwen W. Method for extracting anticancer extract from citronella oil, composition and use thereof. CN 1970054 A, 2010.
[26]
Feng East Hua. Mosquito repelling patch and preparation technology thereof. CN 102165964 A, 2011.
[27]
Setiawati W, Murtiningsih R, Hasyim A. Laboratory and field evaluation of essential oils from Cymbopogon nardus as oviposition deterrent and ovicidal activities against Helicoverpa armigera Hubner on chili pepper. Indones J Agric Sci 2011; 12(1): 9-16.
[28]
Silva CF, Moura FC, Mendes MF, Pessoa FL. Extraction of citronella (Cymbopogon nardus) essential oil using supercritical CO2: Experimental data and mathematical modeling. Braz J Chem Eng 2011; 28(2): 343-50.
[29]
Sakulku U, Nuchuchua O, Uawongyart N, Puttipipatkhachorn S, Soottitantawat A, Ruktanonchai U. Characterization and mosquito repellent activity of citronella oil nanoemulsion. Int J Pharm 2009; 372(1): 105-11.
[30]
Gillij YG, Gleiser RM, Zygadlo JA. Mosquito repellent activity of essential oils of aromatic plants growing in Argentina. Bioresour Technol 2008; 99(7): 2507-15.
[31]
Thanaboripat D, Mongkontanawut N, Suvathi Y, Ruangrattametee V. Inhibition of aflatoxin production and growth of Aspergillus flavus by citronella oil. KMITL Sci J 2004; 4(1): 1-8.
[32]
Wany A, Jha S, Nigam VK, Pandey DM. Chemical analysis and therapeutic uses of citronella oil from Cymbopogon winterianus: A short review. IJAR 2013; 1(6): 504-21.
[33]
Jaroenkit P, Matan N, Nisoa M. In vitro and in vivo activity of citronella oil for the control of spoilage bacteria of semi dried round scad (Decapterus maruadsi). IJMAP 2011; 1(3): 234-9.
[34]
Jeyathilakan N, Murali K, Anandaraj A, Latha BR, Basith SA. Anthelmintic activity of essential oils of Cymbopogan nardus and Azadirachta indica on Fasciola gigantica. J Vet Anim Sci 2010; 6(6): 204-9.
[35]
Hudson JB. Antiviral compounds from plants. CRC Press, Inc. 1990.
[36]
Aini MN, Said MI, Nazlina I, Hanina MN, Ahmad IB. Screening for antiviral activity of sweet lemon grass (Cymbopogon nardus (L.) Rendle) fractions. J Biol Sci 2006; 6(3): 507-10.
[37]
Entigu R, Ahmad IB. The antiviral activities of cymbopogon nardus against measles virus.14th-15. 104, 2009.
[38]
Singh BR, Agrawal R, Prasannavadhana BM, Dubey S. Antimicrobial Activity of Citronella Essential Oil on Antimicrobial Drug Resistant Bacteria from Veterinary Clinical Cases. Clin Med Biochem 2015; 1(106): 2.
[39]
Citronella (Oil of Citronella) (021901) Fact Sheet. Avaialble from: https://www3.epa.gov /pesticides /chem_search/reg_actions/registration/fs_PC-021 901_01-Nov-99.pdf
[40]
Reegan AD, Kannan RV, Paulraj MG, Ignacimuthu S. Synergistic effects of essential oil-based cream formulations against Culex quinquefasciatus Say and Aedes aegypti L.(Diptera: Culicidae). J Asia Pac Entomol 2014; 17(3): 327-31.
[41]
WHO G. Report of the WHO Informal Consultation on the evaluation and testing of insecticides. World Health Organization Geneva. 1996 Oct 7.
[42]
Rani N, Wany A, Vidyarthi AS, Pandey DM. Study of Citronella leaf based herbal mosquito repellents using natural binders. Curr Res Microbiol Biotechnol 2013; 1(3): 98-103.
[43]
Yadav NP, Rai VK, Mishra N, et al. A novel approach for development and characterization of effective mosquito repellent cream formulation containing citronella oil. BioMed Res Int 2014; 2014786084
[44]
Hsu WS, Yen JH, Wang YS. Formulas of components of citronella oil against mosquitoes (Aedes aegypti). J Environ Sci Health B 2013; 48(11): 1014-9.
[45]
Luangnarumitchai S, Lamlertthon S, Tiyaboonchai W. Antimicrobial activity of essential oils against five strains of Propionibacterium acnes. J Pharm Sci 2007; 34(1-4): 60-4.
[46]
Patel JB, Cockkerill FR, Alder J, et al. Performance standards for antimicrobial susceptibility testing; twenty-fourth informational supplement. CLSI standards for antimicrobial susceptibility testing 2014; 34(1): 1-226.
[47]
Pattnaik S, Subramanyam VR, Kole C. Antibacterial and antifungal activity of ten essential oils in vitro. Microbios 1995; 86(349): 237-46.
[48]
Nickavar B, Abolhasani L, Izadpanah H. α-Amylase Inhibitory Activities of Six Salvia Species. Iran J Pharm Res 2008; 7(4): 297-303.
[49]
Jumepaeng T, Prachakool S, Luthria DL, Chanthai S. Determination of antioxidant capacity and α-amylase inhibitory activity of the essential oils from citronella grass and lemongrass. IFRJ 2013; 20(1): 481-5.
[50]
Carlini EA. Plants and the central nervous system. Pharmacol Biochem Behav 2003; 75(3): 501-12.
[51]
Umezu T, Ito H, Nagano K, et al. Anticonflict effects of rose oil and identification of its active constituents. Life Sci 2002; 72(1): 91-102.
[52]
De Almeida Nóbrega R, Motta SC, Leite JR. Óleosessenciais com propriedades anti convulsivantes. BoletínLatinoamericano y del Caribe de PlantasMedicinales y Aromáticas 2003; 2(1)
[53]
de Sousa DP, Gonçalves JC, Quintans-Júnior L, Cruz JS, Araújo DA, de Almeida RN. Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents. Neurosci Lett 2006; 401(3): 231-5.
[54]
Silva MR, Ximenes RM, da Costa JG, Leal LK, de Lopes AA, de Barros Viana GS. Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf in mice. Naunyn Schmiedebergs Arch Pharmacol 2010; 381(5): 415-26.
[55]
Kpoviessi S, Bero J, Agbani P, et al. Chemical composition, cytotoxicity and in-vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from benin. J Ethnopharmacol 2014; 151(1): 652-9.
[56]
Kandimalla R, Kalita S, Choudhury B, Dash S, Kalita K, Kotoky J. Chemical composition and anti-candidiasis mediated wound healing property of Cymbopogon nardus essential oil on chronic diabetic wounds. Front Pharmacol 2016; 7: 198.
[57]
Lertsatitthanakorn P, Aromdee C, Khunkitti W. Formulation optimization of citronella grass oil solid lipid particles using mixture design. Vertex 2013; 9(4.2): 396-402.
[58]
Specos MM, Garcia JJ, Tornesello J, et al. Microencapsulated citronella oil for mosquito repellent finishing of cotton textiles. Trans R Soc Trop Med Hyg 2010; 104(10): 653-8.
[59]
Solomon B, Sahle FF, Gebre-Mariam T, Asres K, Neubert RH. Microencapsulation of citronella oil for mosquito-repellent application: formulation and in vitro permeation studies. Eur J Pharm Biopharm 2012; 80(1): 61-6.
[60]
Hsieh WC, Chang CP, Gao YL. Controlled release properties of chitosan encapsulated volatile citronella oil microcapsules by thermal treatments. Colloids Surf B 2006; 53(2): 209-14.
[61]
Songkro S, Hayook N, Jaisawang J, Maneenuan D, Chuchome T, Kaewnopparat N. Investigation of inclusion complexes of citronella oil, citronellal and citronellol with β-cyclodextrin for mosquito repellent. J Incl Phenom Macrocycl Chem 2012; 72(3-4): 339-55.
[62]
Environmental Protection Agency, R.E.D. Facts. Available from: nepis.epa.gov/ Exe/ZyPURL. cgi?Dockey=30006B55.TXT
[63]
Alternative Medicine Available from: http://www.altmedicine.org/
[64]
Akhila A. editor Essential oil-bearing grasses: the genus Cymbopogon. CRC Press 2009. Aug 26.
[65]
Verdun P, Verdun A. inventors; Verdun Peter C., assignee. Hair and scalp treatment composition. United States patent application US 10/307,588, 2002.
[66]
Lertsatitthanakorn P, Taweechaisupapong S, Aromdee C, Khunkitti W. In vitro bioactivities of essential oils used for acne control. Int J Aromather 2006; 16(1): 43-9.
[67]
National Pesticide Information Centre, Oil of Citronella General Fact Sheet. Available form: http://npic.orst.edu/factsheets/citronellagen.html
[68]
Schlede E, Aberer W, Fuchs T, et al. Chemical substances and contact allergy-244 substances ranked according to allergenic potency. Toxicol 2003; 193(3): 219-59.
[69]
Ishidate M, Harnois MC, Sofuni T. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat Res Genet Toxicol Environ Mutagen 1998; 195(2): 151-213.
[70]
Environmental Protection Act 1997. Available from: http://www.legislation.act.gov.au/a/1997-92/current/pdf/1997-92.pdf
[71]
Manosroi J, Dhumtanom P, Manosroi A. Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines. Cancer Lett 2006; 235(1): 114-20.
[72]
Janssen AM, Scheffer JJ, Svendsen AB. Antimicrobial activity of essential oils: a 1976-1986 literature review. Aspects of the test methods. Planta Med 1987; 53(05): 395-8.

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