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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test

Author(s): Alvaro Gonzalez-Dominguez, Alfonso Maria Lechuga-Sancho and Raul Gonzalez-Dominguez*

Volume 18 , Issue 11 , 2018

Page: [896 - 900] Pages: 5

DOI: 10.2174/1568026618666180711150525

Price: $65

Abstract

Observational experimental designs are usually employed in metabolomics to elucidate pathological mechanisms underlying disease development and to discover candidate biomarkers for diagnosis. However, intervention trials can also be a suitable starting point before performing a validation study in lager epidemiological cohorts, with a great potential in personalized medicine to investigate how different patients respond to similar stimuli. In the present work, we provide a review of the literature on the application of metabolomics to investigate metabolic alterations associated with diabetes, the diabetes predisposing state of insulin resistance and the oral glucose tolerance test as a case study to demonstrate the complementarity of observational and interventional study designs.

Keywords: Metabolomics, Diabetes, Oral glucose tolerance test, Insulin resistance, Study design, Observational study, Interventional study.

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