Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test

Title:Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test

Volume: 18 Issue: 11

Author(s): Alvaro Gonzalez-Dominguez, Alfonso Maria Lechuga-Sancho and Raul Gonzalez-Dominguez*

Affiliation:

• International Campus of Excellence CeiA3, University of Huelva, 21007 Huelva,Spain

Keywords: Metabolomics, Diabetes, Oral glucose tolerance test, Insulin resistance, Study design, Observational study, Interventional study.

Abstract: Observational experimental designs are usually employed in metabolomics to elucidate pathological mechanisms underlying disease development and to discover candidate biomarkers for diagnosis. However, intervention trials can also be a suitable starting point before performing a validation study in lager epidemiological cohorts, with a great potential in personalized medicine to investigate how different patients respond to similar stimuli. In the present work, we provide a review of the literature on the application of metabolomics to investigate metabolic alterations associated with diabetes, the diabetes predisposing state of insulin resistance and the oral glucose tolerance test as a case study to demonstrate the complementarity of observational and interventional study designs.

Cite this article as:

Gonzalez-Dominguez Alvaro, Lechuga-Sancho Maria Alfonso and Gonzalez-Dominguez Raul*, Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test, Current Topics in Medicinal Chemistry 2018; 18(11) . https://dx.doi.org/10.2174/1568026618666180711150525