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Current Analytical Chemistry


ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Review Article

An Overview on Analytical Methods for Quantitative Determination of Aristolochic Acids

Author(s): Mohammad-Reza Afshar-Mogaddam, Adeleh Yadeghari and Abolghasem Jouyban*

Volume 16 , Issue 5 , 2020

Page: [533 - 544] Pages: 12

DOI: 10.2174/1573411014666180704124213

Price: $65


Background: Aristolochic acids are chemically linked to nitrophenanthrene carboxylic acids which are found in aristolochia plants. These compounds are intrinsically carcinogenic, while they have been used in traditional medicine from a long time ago. Despite the beneficial effects of herbals for treating some diseases, they possess some side effects.

Methods: Therefore, the development of a sensitive and selective procedure for the determination of these harmful components in various complicated samples is an important task for health systems and drug authorities. In the past years, ultra-pressure liquid chromatography, high performance liquid chromatography and capillary electrophoresis with different detection systems were used for determination of aristolochic acids in various samples.

Results: In this review, different analytical methods have been discussed in brief and applications of them in diverse samples have been summarized.

Conclusion: Different approaches are compared from point of sensitivity, selectivity, and extraction efficiency.

Keywords: Aristolochic acids, capillary electrophoresis, high-performance liquid chromatography, sample preparation, ultraperformance liquid chromatography, review.

Graphical Abstract
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