Abstract
Humans have long sought means to extend longevity and counteract the effects of aging on physical and mental functioning. Exercise is a highly effective way of treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. Interestingly, the Klotho gene is involved in the aging process. Indeed, overexpression of the Klotho gene is associated with longevity, and experimental animals lacking this gene seem to develop multiple disorders resembling human aging and present a shortened lifespan. Three Klotho-related genes have been identified: α-Klotho, β-Klotho, and γ-Klotho. Exercise seems to play a key role on the secreted form of the α-Klotho gene (S-Klotho) in animal models as well as in humans. We systematically reviewed the available evidence on the associations between exercise and S-Klotho protein regulation.
Keywords: Anti-aging, fitness, physical activity, S-Klotho, biomarkers, health, age.
Current Aging Science
Title:Role of Exercise on S-Klotho Protein Regulation: A Systematic Review
Volume: 11 Issue: 2
Author(s): Francisco J. Amaro-Gahete*, Alejandro de-la-O, Lucas Jurado-Fasoli, Jonatan R. Ruiz, Manuel J. Castillo and Ángel Gutiérrez
Affiliation:
- Department of Medical Physiology, Faculty of Medicine, University of Granada, Granada,Spain
Keywords: Anti-aging, fitness, physical activity, S-Klotho, biomarkers, health, age.
Abstract: Humans have long sought means to extend longevity and counteract the effects of aging on physical and mental functioning. Exercise is a highly effective way of treating and preventing the main causes of morbidity and mortality, most of which are associated with aging. Interestingly, the Klotho gene is involved in the aging process. Indeed, overexpression of the Klotho gene is associated with longevity, and experimental animals lacking this gene seem to develop multiple disorders resembling human aging and present a shortened lifespan. Three Klotho-related genes have been identified: α-Klotho, β-Klotho, and γ-Klotho. Exercise seems to play a key role on the secreted form of the α-Klotho gene (S-Klotho) in animal models as well as in humans. We systematically reviewed the available evidence on the associations between exercise and S-Klotho protein regulation.
Export Options
About this article
Cite this article as:
Amaro-Gahete J. Francisco*, de-la-O Alejandro , Jurado-Fasoli Lucas, Ruiz R. Jonatan , Castillo J. Manuel and Gutiérrez Ángel , Role of Exercise on S-Klotho Protein Regulation: A Systematic Review, Current Aging Science 2018; 11 (2) . https://dx.doi.org/10.2174/1874609811666180702101338
DOI https://dx.doi.org/10.2174/1874609811666180702101338 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Glucose Transporters in Sex Steroid Hormone Related Cancer
Current Vascular Pharmacology Angiotensin Converting Enzyme 2 Activator (DIZE) Modulates Metabolic Profiles in Mice, Decreasing Lipogenesis
Protein & Peptide Letters The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases
Anti-Infective Agents in Medicinal Chemistry Small Interfering RNA for Effective Cancer Therapies
Mini-Reviews in Medicinal Chemistry The Hypothalamus and Obesity
Recent Patents on CNS Drug Discovery (Discontinued) Investigation of In Vitro Antiurolithic Property of Purified Polyphenols from Selected Medicinal Plants to Inhibit Renal Calculi
Current Traditional Medicine Patents and Recent Innovations in Topical Membrane Therapy of Refractory Rhinosinusitis
Recent Patents on Inflammation & Allergy Drug Discovery Meal Replacement Beverage Twice a Day in Overweight and Obese Adults (MDRC2012-001)
Current Nutrition & Food Science Alpha-Particle Microdosimetry
Current Radiopharmaceuticals PPAR-Gamma in Ulcerative Colitis: A Novel Target for Intervention
Current Drug Targets Equibiotic-GI Consumption Improves Intestinal Microbiota in Subjects with Functional Dyspepsia
Current Drug Therapy Characterization and Expression Analysis of Receptor for Activated C Kinase from Silk-producing Insect Antheraea pernyi
Protein & Peptide Letters TGR5 as a Therapeutic Target for Treating Obesity
Current Topics in Medicinal Chemistry Induction of Cytochromes P450
Current Topics in Medicinal Chemistry The Possible Effects of Dapagliflozin on 12-derived Electrocardiogram in Patients with Type 2 Diabetes Mellitus
Endocrine, Metabolic & Immune Disorders - Drug Targets Genome-wide Membrane Protein Structure Prediction
Current Genomics Dysregulation of Angiopoietin-like-4 Associated with Hyperlipidemia-induced Renal Injury by AMPK/ACC Pathway
Current Pharmaceutical Design A Recombinant Fab Antibody Against Kwakhurin as a Tool for Sensitive Indirect Competitive ELISA
Current Pharmaceutical Biotechnology Autologous Fat Transfer and Cell-Based Strategies for Soft Tissue Reconstruction
Current Tissue Engineering (Discontinued) Editorial [Hot Topic: Recent Progress in the Development of Anti-Diabetic Drugs (Guest Editor: J. Eckel)]
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents