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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Exploring the Benefits of Cellular Models to Uncover Bioactive Polyphenols for Neurodegeneration

Author(s): Rita Rosado-Ramos, Joana Godinho-Pereira, Ines Figueira, Carolina Jardim, Goncalo Garcia and Regina Menezes*

Volume 24 , Issue 19 , 2018

Page: [2076 - 2106] Pages: 31

DOI: 10.2174/1381612824666180629112148

Price: $65

Abstract

Our society is currently experiencing increased lifespan; one of the top causes for the high incidence of neurodegenerative disorders. The lack of effective treatments delaying or blocking disease progression has encouraged the active search for novel therapies. Many evidences support the protective role of phytochemicals in the prevention of neurodegenerative diseases, particularly (poly)phenols. In this review, we described the use of cellular-based models of neurodegenerative diseases and the benefits of their use as potent tools in the search for bioactive molecules, particularly (poly)phenols. Studies to assess the biological activity of (poly)phenols involve experimentation with in vitro and in vivo systems. In vitro systems are a useful tool as a first approach to test the underlined molecular mechanisms of candidate molecules. They can provide valuable information about biological activity, which can be then used to design animal and human intervention studies.

Keywords: 2D and 3D cells models, neurodegenerative diseases, oxidative stress, polyphenol, yeast, phytochemicals.


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