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Current Nutrition & Food Science


ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Research Article

Hypotensive Effect of Hydroalcoholic Ziziphus jujuba Extract on Normotensive Rats

Author(s): Reza Mohebbati, Maryam Rahimi, Kosar Bavarsad, Farimah Beheshti, Abolfazl KhajaviRad and Mohammad N. Shafei*

Volume 15, Issue 7, 2019

Page: [712 - 717] Pages: 6

DOI: 10.2174/1573401314666180620162733

Price: $65


Objective: Ziziphus jujuba (Z.J) is a medicinal plant with several properties such as antioxidant, antibacterial, hypnotic and wound healing activity. It also has lowering blood pressure effect and people use it to treat hypertension. In the present study, the effect of hydroalcoholic extract of Z.J on cardiovascular parameters in the normotensive rats was investigated.

Methods: Animal groups include: 1) Sham, only cannulation of artery 2) saline, received saline for four weeks 3-5) Z.J groups (100, 200 and 400 mg/kg) that treated with Z.J via gavage for four weeks. In the experiment day (28th Day) femoral artery of all rats cannulated and Systolic Blood Pressure (SBP), Mean Atrial Pressure (MAP) and Heart Rate (HR) recorded by a power lab system. The weight of animal in all groups also was recorded in the beginning and the last day of experiment.

Results: There was no significant difference in HR, SBP and MAP parameters between sham and control groups. The SBP and MAP in higher doses of Z.J (200 and 400 mg) significantly decreased compared to control group. The HR only in dose 200 mg of Z.J significantly decreased than the control group.

Conclusion: The results of present study show that hydroalcoholic extract of Z.J has an inhibitory effect on basal cardiovascular parameters and its best effects have been shown in dose 200 mg/kg.

Keywords: Heart rate, mean atrial pressure, rat, systolic blood pressure, Ziziphus jujuba, hypertension.

Graphical Abstract
Unwin N, Setel P, Rashid S, et al. Noncommunicable diseases in sub-Saharan Africa: where do they feature in the health research agenda? Bull World Health Organ 2001; 79: 947-53.
Mohammadi E, Abedi HA, Gofranipour F, Jalali F. Partnership caring: a theory of high blood pressure control in Iranian hypertensives. Int J Nurs Pract 2002; 8: 324-9.
Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003; 289: 2560-71.
Oh J-Y, Hong YS, Sung Y-A, Barrett-Connor E. Prevalence and factor analysis of metabolic syndrome in an urban Korean population. Diabetes Care 2004; 27: 2027-32.
Ordúñez P, Silva LC, Rodríguez MP, Robles S. Prevalence estimates for hypertension in Latin America and the Caribbean: are they useful for surveillance? Rev Panam Salud Publ 2001; 10: 226-31.
Whelton PK. Epidemiology of hypertension. Lancet 1994; 344: 101-6.
Rodefeld MD, Beau SL, Schuessler RB, Boineau JP, Saffitz JE. β‐adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node. J cardiovascular electrophysiol 1996; 7: 1039-49.
Brodde O-E, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev 1999; 51: 651-90.
Messerli FH, Grossman E, Goldbourt U. Are β-blockers efficacious as first-line therapy for hypertension in the elderly?: a systematic review. JAMA 1998; 279: 1903-7.
Leweke FM, Gerth CW, Koethe D, Faulhaber J. KlosterkÖtter J. Oxcarbazepine as an adjunct for schizophrenia. Am J Psychiatry 2004; 161: 1130-1.
Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Mbewu A, Opie LH. Beta-blockers for hypertension. Cochrane Database Syst Rev 2012; 8CD002003
Alvani S, Mahdikhani-Moghadam E, Rouhani H, Mohammadi A, Eds. First preliminary study of plant parasitic nematodes of Zizyphus zizyphus in the world from southern Khorasan provinces in Iran. The Second International Conference on Agriculture and Natural Resources. Razi University, Kermanshah, Iran 2013.
Mukhtar HM, Ansari S, Ali M, Naved T. New compounds from Zizyphus vulgaris. Pharma Biol 2004; 42: 508-11.
San B, Yildirim AN, Polat M, Yildirim F. Mineral composition of leaves and fruits of some promising Jujube (Zizyphus jujuba miller) genotypes. Asian J Chem 2009; 21: 2898.
Abdel-Zaher AO, Salim SY, Assaf MH, Abdel-Hady RH. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol 2005; 101: 129-38.
Yuan R, Lin Y. Traditional Chinese medicine: an approach to scientific proof and clinical validation. Pharmacol Ther 2000; 86: 191-8.
Ali NA, Jülich W-D, Kusnick C, Lindequist U. Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. J Ethnopharmacol 2001; 74: 173-9.
Kalt W, Forney CF, Martin A, Prior RL. Antioxidant capacity, vitamin C, phenolics, and anthocyanins after fresh storage of small fruits. J Agric Food Chem 1999; 47: 4638-44.
Mohebbati R, Shafei MN, Soukhtanloo M, Roshan NM, Rad AK, Anaeigoudari A, et al. Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney. Avicenna J Phytomed 2016; 6: 86.
Behradmanesh S, Nasri P. Serum cholesterol and LDL-C in association with level of diastolic blood pressure in type 2 diabetic patients. J Renal Inj Prev 2012; 1: 23-6.
Mahmoudabady M, Shafei MN, Niazmand S, Khodaee E. The effects of hydroalchoholic extract of Teucrium polium L. on hypertension induced by angiotensin II in rats. Int J prev med 2014; 5: 1255.
Goyal R, Sharma PL, Singh M. Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. J nat med 2011; 65: 514-8.
Gao Q-H, Wu C-S, Wang M. The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits. J Agric Food Chem 2013; 61: 3351-63.
Preeti Tripathi S. Ziziphus jujuba: a phytopharmacological review. 2014; 3(3): 959-66.
Mahajan RT, Chopda M. Phyto-pharmacology of Ziziphus jujuba Mill-a plant review. Pharmacog Rev 2009; 3: 320.
Rovnyak GC, Atwal KS, Hedberg A, et al. Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1, 4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents. J Med Chem 1992; 35: 3254-63.
Maragos CM, Morley D, Wink DA, et al. Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 1991; 34: 3242-7.
Fu J-Y, Qian L-B, Zhu L-G, et al. Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress. Eur J Pharm Sci 2011; 44: 385-91.
Memarpoor-Yazdi M, Mahaki H, Zare-Zardini H. Antioxidant activity of protein hydrolysates and purified peptides from Zizyphus jujuba fruits. J Functional Foods 2013; 5: 62-70.
Zhu Y. Chinese Materia Medica: Chemistry, Pharmacology, and Applications. Harwood Academic Publishers Amsterdam 1998.

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