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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

New Approaches for Weight Loss: Experiments Using Animal Models

Author(s): Magnus K. Olsen*, Helene Johannessen, Reshma Ramracheya, Chun-Mei Zhao and Duan Chen

Volume 24 , Issue 18 , 2018

Page: [1926 - 1935] Pages: 10

DOI: 10.2174/1381612824666180614075412

Price: $65


The number of people who are overweight and obese are continuously increasing both in the adult and adolescent populations. Coinciding with this is the increased prevalence of health problems such as type 2 diabetes (T2D). Bariatric surgery is the only proven long-term treatment of obesity and may induce remission of T2D, although the underlying mechanisms are unknown. The translational studies presented here might provide insight on the mechanism of steady-state energy balance of the obese phenotype using a special time-restricted feeding regimen for weight loss during the steady-state energy balance; mechanism by vagal blocking therapy (vBLoc® therapy) as a new treatment for obesity; and possible mechanism behind the remission of T2D following gastric bypass surgery.

Keywords: Energy balance, PYY, time-restricted feeding, vagus nerve, obese, bariatric surgery.

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