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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Research Article

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Author(s): Salma E. Ahmed, Nahid Awad, Vinod Paul, Hesham G. Moussa and Ghaleb A. Husseini*

Volume 18, Issue 10, 2018

Page: [857 - 880] Pages: 24

DOI: 10.2174/1568026618666180608125344

Price: $65


Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

Keywords: Chemotherapy, multi-drug resistance, anthracyclines, doxorubicin, nano-carriers, ultrasound.

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