Abstract
The streptogramin antibiotics were discovered over 40 years ago but are only now emerging as important therapeutic agents for the treatment of infection caused by a variety of bacteria. The streptogramins consist of mixtures of two structurally distinct compounds, type A and type B, which are separately bacteriostatic, but bactericidal in appropriate ratios. These antibiotics act at the level of inhibition of translation through binding to the bacterial ribosome. Resistance to streptogramins occurs through a number of mechanisms including target modification, efflux, and enzyme catalyzed antibiotic modification. This review describes the current understanding of streptogramin function and resistance with emphasis on molecular mechanism and epidemiology.
Keywords: Streptogramin Antibiotics, bacteriostatic, bactericidal
Current Drug Targets
Title: Streptogramin Antibiotics: Mode of Action and Resistance
Volume: 3 Issue: 4
Author(s): Nicole J. Johnston, Tariq A. Mukhtar and Gerard D. Wright
Affiliation:
Keywords: Streptogramin Antibiotics, bacteriostatic, bactericidal
Abstract: The streptogramin antibiotics were discovered over 40 years ago but are only now emerging as important therapeutic agents for the treatment of infection caused by a variety of bacteria. The streptogramins consist of mixtures of two structurally distinct compounds, type A and type B, which are separately bacteriostatic, but bactericidal in appropriate ratios. These antibiotics act at the level of inhibition of translation through binding to the bacterial ribosome. Resistance to streptogramins occurs through a number of mechanisms including target modification, efflux, and enzyme catalyzed antibiotic modification. This review describes the current understanding of streptogramin function and resistance with emphasis on molecular mechanism and epidemiology.
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Cite this article as:
Johnston J. Nicole, Mukhtar A. Tariq and Wright D. Gerard, Streptogramin Antibiotics: Mode of Action and Resistance, Current Drug Targets 2002; 3 (4) . https://dx.doi.org/10.2174/1389450023347678
DOI https://dx.doi.org/10.2174/1389450023347678 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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