Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma

Title:Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma

Volume: 24 Issue: 19

Author(s): Amir Abbas Momtazi-Borojeni, Faezeh Ghasemi, Amirreza Hesari, Muhammed Majeed, Michele Caraglia and Amirhossein Sahebkar*

Affiliation:

• Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564,Iran

Keywords: Apoptosis, curcumin, nasopharyngeal cancer, non-coding RNA, tropical, chemotherapy.

Abstract: Nasopharyngeal Cancer (NPC) is a rare type of head and neck cancer that is mainly treated by radiotherapy, but sometimes it is radioresistant. Curcumin is a polyphenolic natural product with established anticancer effects in various human cancers. Recent studies have shown that curcumin has therapeutic and radiosensitizing effects on NPC cells. In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs. As curcumin is safe and lacks systemic toxic effects in humans, it may be considered as a potential candidate to enhance the therapeutic effects of radiation and potentiate the efficacy of chemotherapy in the context of combination regimens.

Cite this article as:

Momtazi-Borojeni Abbas Amir , Ghasemi Faezeh, Hesari Amirreza , Majeed Muhammed , Caraglia Michele and Sahebkar Amirhossein *, Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma, Current Pharmaceutical Design 2018; 24 (19) . https://dx.doi.org/10.2174/1381612824666180522105202