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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Cocrystal and its Application in the Field of Active Pharmaceutical Ingredients and Food Ingredients

Author(s): Na Wang, Chuang Xie, Haijiao Lu, Nannan Guo, Yajing Lou, Weiyi Su and Hongxun Hao*

Volume 24 , Issue 21 , 2018

Page: [2339 - 2348] Pages: 10

DOI: 10.2174/1381612824666180522102732

Price: $65

Abstract

Background: The development of solid drug dosage form and food ingredients is constrained by their low solubility, low dissolution, low bioavailability and poor physicochemical properties. Formation of cocrystal is a novel and promising method to enhance and improve the properties of materials without breaking the covalent bonds.

Methods: The goal of this review is to summarize the cocrystals and their applications in the field of Active Pharmaceutical Ingredients (APIs) and food ingredients (AFIs), mainly on the effective improvements of APIs’ and AFIs’ pharmacokinetic, physicochemical and mechanical properties by the formation of cocrystals.

Results: After years of research and development on cocrystals in the area of pharmaceutical and food industries, significant progress has been made. Formation of cocrystal is an efficient method for improving the solubility, dissolution rate, permeability and in vivo bioavailability of APIs and AFIs, as well as for enhancing stability and mechanical properties.

Conclusion: Cocrystals exhibit complex structures which can conspicuously affect the physical and chemical properties of original substance, with good clinical performance and outstanding stability during processing and storage.

Keywords: Cocrystals, APIs, AFIs, solubility, dissolution, permeability, bioavailability, stability.


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