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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

The Hydrocarbon Staple & Beyond: Recent Advances Towards Stapled Peptide Therapeutics that Target Protein-Protein Interactions

Author(s): Robert A. Hillman, Jonathan W. Nadraws and Michael A. Bertucci*

Volume 18, Issue 7, 2018

Page: [611 - 624] Pages: 14

DOI: 10.2174/1568026618666180518095255

Price: $65


Anomalous protein-protein interactions (PPIs) have been correlated to a variety of disease states, such as cancer, infectious disease, neurological disorders, diabetes, endocrine disorders and cardiovascular disease. Stapled peptides are an emerging intervention for these PPIs due to their improved structural rigidity and pharmacokinetic properties relative to unstapled peptides. This review details the most recent advances in the field of stapled peptide therapeutics, including the increasing variety of PPIs being targeted and types of peptide staples being employed.

Keywords: Stapled peptides, protein-protein interactions, peptide therapeutics, hydrocarbon, infectious disease, cancer.

Graphical Abstract

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