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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Polyphenols, their Metabolites and Derivatives as Drug Leads

Author(s): A. Filipa Almeida, Claudia Nunes dos Santos and Maria Rita Ventura*

Volume 24 , Issue 19 , 2018

Page: [2188 - 2207] Pages: 20

DOI: 10.2174/1381612824666180516103609

Price: $65


In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.

Keywords: Polyphenols, polyphenol metabolites, chemical synthesis, medicinal chemistry, drugs, anticancer.

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