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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Role of Formyl Peptide Receptors in Gastrointestinal Healing

Author(s): ">N. Prevete, A. de Paulis, ">D. Sgambato, ">R.M. Melillo, G. D`Argenio, ">L. Romano, R.M. Zagari and ">M. Romano*

Volume 24 , Issue 18 , 2018

Page: [1966 - 1971] Pages: 6

DOI: 10.2174/1381612824666180516102234

Price: $65

Abstract

The wound healing and the barrier restoration of the gastrointestinal (GI) mucosa must be continuously ensured to allow homeostasis of the gastrointestinal tract and of all the surrounding tissues. Several lines of the evidence report a key role of innate immunity, and in particular of Pattern Recognition Receptors (PRRs), in controlling the homeostasis of GI tract by sensing commensal and pathogen bacteria, activating the immune response and regulating epithelial repair, thus guaranteeing the morphological and functional recovery of the injured tissue. We will discuss the role of a particular class of PRRs - the Formyl Peptide Receptors - in the homeostasis of GI mucosa. We here report the results of studies that strongly suggest the possibility that the activation of FPRs is crucial in the maintenance of homeostasis of the GI tract and provide indications of the potential clinical relevance of new treatment regimens involving FPR modulation for several GI disorders.

Keywords: Gastrointestinal tract, formyl peptide receptors, wound healing, homeostasis, epithelial repair, pattern recognition receptors (PRRs).


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