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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans

Author(s): Nikoletta Papaevgeniou and Niki Chondrogianni*

Volume 24 , Issue 19 , 2018

Page: [2107 - 2120] Pages: 14

DOI: 10.2174/1381612824666180515145652

Price: $65

Abstract

Polyphenols constitute a group of compounds that have been highly investigated for their beneficial effects against various pathologic and non-pathologic conditions and diseases. Among their multi-faceted properties, their anti-oxidant potential nominates them as ideal protective candidates for conditions characterized by elevated levels of oxidative stress, including aging and age-related diseases. The nematode Caenorhabditis elegans is a multicellular model organism that is highly exploited in studies related to aging and age-associated pathologies. In this review, we will summarize studies where polyphenolic compounds have been tested for their anti-aging potential and their protective role against the progression of age-related diseases using C. elegans as their main model.

Keywords: Aging, senescence, aggregation, age-related diseases, C. elegans, polyphenols, longevity, stress resistance.


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