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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Bcl-2-Related Proteins as Drug Targets

Author(s): Jason W. O'Neill and David M. Hockenbery

Volume 10, Issue 16, 2003

Page: [1553 - 1562] Pages: 10

DOI: 10.2174/0929867033457241

Price: $65

Abstract

The Bcl-2 family of proteins provide the most unambiguous link between mitochondrial functions and apoptosis, as their only (or principal) functions appear to be as regulators of this cell death pathway. Rational drug design to manipulate the functions of these proteins has been hampered by the lack of a clear understanding of a biochemical or molecular function, with disruption of intra-family protein-protein interactions as the only known, but daunting, objective. There has been substantial progress in this task using molecular modeling and drug leads. The prospects are also good for development of chemical tools for functional analysis of the Bcl-2 proteins.

Keywords: bcl-2-related proteins, bcl-2 family, apoptosis, intra-family protein-protein, chemical tools, bcl-2 proteins


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