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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

General Review Article

Heterocyclic N-oxides - A Promising Class of Agents against Tuberculosis, Malaria and Neglected Tropical Diseases

Author(s): Guilherme Felipe dos Santos Fernandes, Aline Renata Pavan and Jean Leandro dos Santos*

Volume 24 , Issue 12 , 2018

Page: [1325 - 1340] Pages: 16

DOI: 10.2174/1381612824666180417122625

Price: $65


Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxides are described herein, nevertheless, the following chemical classes deserve to be highlighted due to a large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide. In order to describe those most promising compounds, we included in this review only those most biologically active heterocyclic Noxide published since 2000.

Keywords: Heterocyclic N-oxides, N-oxide compounds, tuberculosis, malaria, neglected tropical diseases, leishmaniasis, Chagas disease, drug discovery.

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