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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection

Author(s): Ana Claudia Torrecilhas, Patricia Xander, Karen Spadari Ferreira and Wagner Luiz Batista*

Volume 18 , Issue 4 , 2018

Page: [300 - 311] Pages: 12

DOI: 10.2174/1568026618666180412154519

Price: $65


The neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of alternative methods for testing new compounds against these diseases. For the implementation of alternative methods, it is necessary to apply the principles of replacement, reduction and refinement (the 3Rs) for the use of laboratory animals. Accordingly, the present review addressed a variety of alternative models to study the infections caused by protozoa and fungi. Overall, vertebrate and invertebrate models of fungal infection have been used to elucidate host-pathogen interactions. However, until now the insect model has not been used in protozoal studies as an alternative method, but there is interest in the scientific community to try new tools to screen alternative drugs to control and prevent protozoal infections.

Keywords: Fungal, leishmaniasis, Chagas disease, alternative methods, alternative host models, target-based approach.

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