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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years

Author(s): Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*

Volume 18 , Issue 2 , 2018

Page: [124 - 148] Pages: 25

DOI: 10.2174/1568026618666180329115523

Price: $65


Coumarins are natural products characterized as 1,2 benzopyrones widely distributed in plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic procedures allow the discovery of coumarins with expanded chemical space. The ability to exert noncovalent interactions with many enzymes and receptors in live organisms lead the coumarins to exhibit a wide range of biological activities and applications. Then, this manuscript provides an overview of the use of coumarins compounds in medicinal chemistry in treating many diseases. Important examples of the last years have been selected concerning the activities of coumarins as anticoagulant, anticancer, antioxidant, antiviral, anti-diabetics, anti-inflammatory, antibacterial, antifungal and anti-neurodegerative agents. Additionally, it also includes applications of coumarins as fluorescent sensors for biological systems. Thus, this work aims to contribute to the development of new rational research projects for the treatment and diagnosis of pathologies using coumarin derivatives.

Keywords: Coumarins, biological activity, fluorescent sensors, structure–activity relationship, fungi, enzymes.

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