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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Research Article

Synthesis, Nematicidal Activity and Docking Study of Novel Pyrazole-4-Carboxamide Derivatives Against Meloidogyne incognita

Author(s): Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng* and Xing-Hai Liu*

Volume 16, Issue 1, 2019

Page: [29 - 35] Pages: 7

DOI: 10.2174/1570180815666180326150827

Price: $65

Abstract

Background: A series of novel 2,6-dichloro-4-(trifluoromethyl)phenyl)-3-(difluoromethyl)- 1H-pyrazole-4-carboxamide derivatives were designed and synthesized.

Methods: All the title compounds were confirmed by 1H NMR and MS.

Results and Conclusion: The primarily nematicidal activity results indicated that some of them exhibited moderate control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita.

Keywords: Difluoromethylpyrazole, alkyl chain, nematicidal activity, synthesis, docking, Meloidogyne incognita.

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