Abstract
The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds. The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.
Keywords: Sonogashira, palladium, Pd-catalyzed, Cu-catalyzed, Cu-free, 2-Formyl/acetyl-N-substituted pyrrolo[2, 3-b]quinoxaline, H-Pyrazolo[5, 1-a]isoquinolines, name reaction.
Graphical Abstract
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