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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Current Applications of the Sonogashira Reaction in the Synthesis of Heterocyclic Compounds: An Update

Author(s): Majid M. Heravi*, Manizheh Ghanbarian, Nastaran Ghalavand and Niousha Nazari

Volume 22, Issue 14, 2018

Page: [1420 - 1457] Pages: 38

DOI: 10.2174/1385272822666180322122232

Price: $65


The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds. The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.

Keywords: Sonogashira, palladium, Pd-catalyzed, Cu-catalyzed, Cu-free, 2-Formyl/acetyl-N-substituted pyrrolo[2, 3-b]quinoxaline, H-Pyrazolo[5, 1-a]isoquinolines, name reaction.

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