Abstract
Carbon monoxide (CO) is a resourceful gas as recent advances in the area of cell signaling are revealing an unexpected physiological role for CO in the cardiovascular, immune and nervous systems. Transition metal carbonyls have been lately discovered to function as COreleasing molecules (CO-RMs) and elicit distinct pharmacological activities in biological systems. Studies currently ongoing in our laboratories are investigating both the chemical and bioactive features of a series of water-soluble CO-RMs and their specific utilization as vasoactive mediators, anti-inflammatory agents and inhibitors of cellular and tissue damage. The data presented in this review corroborate the notion that transition metal carbonyls could be used as carriers to deliver CO in mammals and highlight the bioactivity and potential therapeutic features of CO-RMs in the mitigation of cellular and organ dysfunction.
Keywords: transition metal carbonyls, carbon monoxide-releasing molecules, heme oxygenase, nitric oxide
Current Pharmaceutical Design
Title: Bioactivity and Pharmacological Actions of Carbon Monoxide-Releasing Molecules
Volume: 9 Issue: 30
Author(s): Roberto Motterlini, Brian E. Mann, Tony R. Johnson, James E. Clark, Roberta Foresti and Colin J. Green
Affiliation:
Keywords: transition metal carbonyls, carbon monoxide-releasing molecules, heme oxygenase, nitric oxide
Abstract: Carbon monoxide (CO) is a resourceful gas as recent advances in the area of cell signaling are revealing an unexpected physiological role for CO in the cardiovascular, immune and nervous systems. Transition metal carbonyls have been lately discovered to function as COreleasing molecules (CO-RMs) and elicit distinct pharmacological activities in biological systems. Studies currently ongoing in our laboratories are investigating both the chemical and bioactive features of a series of water-soluble CO-RMs and their specific utilization as vasoactive mediators, anti-inflammatory agents and inhibitors of cellular and tissue damage. The data presented in this review corroborate the notion that transition metal carbonyls could be used as carriers to deliver CO in mammals and highlight the bioactivity and potential therapeutic features of CO-RMs in the mitigation of cellular and organ dysfunction.
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Cite this article as:
Motterlini Roberto, Mann E. Brian, Johnson R. Tony, Clark E. James, Foresti Roberta and Green J. Colin, Bioactivity and Pharmacological Actions of Carbon Monoxide-Releasing Molecules, Current Pharmaceutical Design 2003; 9 (30) . https://dx.doi.org/10.2174/1381612033453785
DOI https://dx.doi.org/10.2174/1381612033453785 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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