2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview

Title:2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview

Volume: 18 Issue: 10

Author(s): Pramod Singh*, Jitendra Singh, Geeta J. Pant*Mohan S.M. Rawat

Affiliation:

• Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand,India

• Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand,India

Keywords: Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.

Abstract: Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.

Cite this article as:

Singh Pramod *, Singh Jitendra , Pant J. Geeta *, Rawat S.M. Mohan , 2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (10) . https://dx.doi.org/10.2174/1871520618666180313153407