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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview

Author(s): Pramod Singh*, Jitendra Singh, Geeta J. Pant* and Mohan S.M. Rawat

Volume 18, Issue 10, 2018

Page: [1366 - 1385] Pages: 20

DOI: 10.2174/1871520618666180313153407

Price: $65


Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.

Keywords: Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.

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