Abstract
Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggested a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamins supplementation should or should be not be recommended for PAD patients.
Keywords: peripheral arterial disease, oxidative stress, antioxidants, atherosclerosis
Current Drug Targets
Title: Antioxidants in Peripheral Arterial Disease
Volume: 4 Issue: 8
Author(s): F. Violi, L. Loffredo, A. Mancini and A. Marcoccia
Affiliation:
Keywords: peripheral arterial disease, oxidative stress, antioxidants, atherosclerosis
Abstract: Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggested a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamins supplementation should or should be not be recommended for PAD patients.
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Cite this article as:
Violi F., Loffredo L., Mancini A. and Marcoccia A., Antioxidants in Peripheral Arterial Disease, Current Drug Targets 2003; 4 (8) . https://dx.doi.org/10.2174/1389450033490786
DOI https://dx.doi.org/10.2174/1389450033490786 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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