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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Oligonucleotide-Based Molecular Therapy for Restenosis after Angioplasty

Author(s): Motokuni Aoki, Ryuichi Morishita and Toshio Ogihara

Volume 4, Issue 8, 2003

Page: [613 - 618] Pages: 6

DOI: 10.2174/1389450033490830

Price: $65

Abstract

Molecular therapy is emerging as a potential strategy for the treatment of cardiovascular disease such as restenosis after angioplasty, vascular bypass graft occlusion, transplant coronary vasculopathy, homozygous familial hypercholesterolemia and cystic fibrosis, for which no known effective therapy exists. Molecular biology and pathophysiology of the cardiovascular system have started to emerge, and the time is ripe for the introduction of gene therapy to the management of cardiovascular disorders. In this review, we have focused on the future potential of oligonucleotide-based gene therapy for restenosis after angioplasty, which still remains an issue in the field of cardiovascular disease.

Keywords: gene therapy, antisense, ribozyme, cis-element decoy, restenosis, e2f


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