摘要
B细胞淋巴瘤2(Bcl-2)家族蛋白在多种细胞外信号和细胞内信号的作用下,在调节细胞凋亡或程序性细胞死亡中发挥着重要作用。这些蛋白质要么是促进凋亡的,要么是抗凋亡的。促进凋亡的Noxa是Bcl-2家族蛋白,属于BH3-纯蛋白的亚类.Noxa通过p53依赖性和/或p53无关机制诱导细胞凋亡。Noxa可能在细胞凋亡中起着有限的作用,但它是凋亡途径中与多种蛋白相互作用的关键分子,在某些癌症的发病和治疗中发挥着重要作用。在这篇综述中,我们将阐明Noxa调控细胞凋亡的机制,并就化疗药物在Noxa中的作用进行综述。
关键词: bcl-2,凋亡,Noxa,癌,B细胞淋巴瘤2,p53.
Current Cancer Drug Targets
Title:Noxa: Role in Cancer Pathogenesis and Treatment
Volume: 18 Issue: 10
关键词: bcl-2,凋亡,Noxa,癌,B细胞淋巴瘤2,p53.
摘要: The B-cell lymphoma 2 (Bcl-2) family proteins play an important role in regulating apoptosis, or programmed cell death, in response to several extracellular and intracellular signals. These proteins are either pro-apoptotic or anti-apoptotic. The pro-apoptotic Noxa is a Bcl-2 family protein that belongs to a subclass of BH3-only proteins. Noxa induces apoptosis via p53-dependent and/or p53-independent mechanisms. While Noxa may play a limited role in apoptosis, it is a crucial player that interacts with several proteins in the apoptosis pathway, highlighting its importance in the pathogenesis and treatment of certain cancers. In this review, we will elucidate the mechanisms by which Noxa regulates apoptosis and review the roles of chemotherapeutic drugs in relation to Noxa.
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Noxa: Role in Cancer Pathogenesis and Treatment, Current Cancer Drug Targets 2018; 18 (10) . https://dx.doi.org/10.2174/1568009618666180308105048
DOI https://dx.doi.org/10.2174/1568009618666180308105048 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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