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Current Drug Safety

Editor-in-Chief

ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Case Studies

A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin

Author(s): Jhanvi J. Vaghela*, Vivek N. Nimbark, Bhavesh C. Chavda, Hita H. Mehta and Bhargav M. Purohit

Volume 13, Issue 2, 2018

Page: [137 - 140] Pages: 4

DOI: 10.2174/1574886313666180302124012

Price: $65

Abstract

Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), also known as Lyell's syndrome, are rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet unclear.

Case Report: A 45-year-old male patient by chance on re-exposure to Ofloxacin developed Severe Cutaneous Adverse Drug Reaction (SCADR), diagnosed with toxic epidermal necrolysis. His comorbid conditions and systemic complications of TEN lead him to death. In developing countries, where antibiotics especially fluoroquinolones are widely prescribed, a physician should be now vigilant for such kind of SCADRs because of increasing numbers of such kind of reports.

Keywords: Toxic epidermal necrolysis, Ofloxacin, SCADR, Fluoroquinolones, Stevens-johnson syndrome, PCNL.

Graphical Abstract

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