摘要
背景:液体活检是一种检测体液中miRNA和无细胞DNA等分子生物标志物的微创检测方法。甲状腺乳头状癌(PTC)是最常见的内分泌恶性肿瘤之一。甲状腺乳头状癌中最常见的突变是BRAF突变。许多研究表明BRAF突变与miRNA的解除调控有关。p53在细胞周期调控、DNA修复和凋亡中具有重要作用。此外,p53还能调节miRNAs的表达,从而参与甲状腺癌的发生。目的:简要总结PTC发病过程中miRNA、BRAF和p53突变的研究现状,以及在液体活检中检测BRAF突变和miRNA表达的可能性。结果:血浆miRNA表达谱与cf-DNA BRAF突变分析相结合,可作为治疗PTC的一种有价值的工具。结论:多种分子变异表征了甲状腺癌的近期诊断、预后指标和治疗靶点,为甲状腺癌创新治疗策略的进一步研究和临床开发提供了独特的机会。
关键词: miRNA,甲状腺乳头状癌,液体活检,BRAF突变,MAPK通路,肿瘤蛋白p53,cf-DNA。
Current Drug Targets
Title:Potential of Liquid Biopsy in Papillary Thyroid Carcinoma in Context of miRNA, BRAF and p53 Mutation
Volume: 19 Issue: 14
关键词: miRNA,甲状腺乳头状癌,液体活检,BRAF突变,MAPK通路,肿瘤蛋白p53,cf-DNA。
摘要: Background: Liquid biopsy is a minimally invasive detection method for molecular biomarkers such as miRNA and cell free DNA in body fluids. Deregulations of miRNA are involved in papillary thyroid carcinoma (PTC), one the most common endocrine malignancy. The most widespread common mutations detected in papillary thyroid cancers are BRAF mutations. Many studies indicate that the BRAF mutation is related to deregulation of miRNA. p53 has an important role in cell cycle control, DNA repair and apoptosis. Moreover, the p53 can regulate the expression of miRNAs and thus participate in thyroid oncogenesis.
Objective: In this review, we briefly summarize the present state of knowledge about miRNA, BRAF and p53 mutation in the development of PTC and the possibility of using detecting BRAF mutation and miRNA expression in liquid biopsy.
Results: The use of the plasma miRNA expression profile in combination with the BRAF mutation analysis in cf-DNA may be a valuable tool in management of PTC.
Conclusion: Numerous molecular variation characterize recent diagnostic and prognostic markers and therapeutic targets for this type of cancer, which offer unique chances for further research and clinical development of innovative treatment strategies for thyroid cancer.
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Cite this article as:
Potential of Liquid Biopsy in Papillary Thyroid Carcinoma in Context of miRNA, BRAF and p53 Mutation, Current Drug Targets 2018; 19 (14) . https://dx.doi.org/10.2174/1389450119666180226124349
DOI https://dx.doi.org/10.2174/1389450119666180226124349 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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