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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Short Communication

Effect of Laser Therapy on Defensins’ Gene Expression in TR146 Epithelial Cell Line

Author(s): Luisa Zupin*, Katia Rupel, Giulia Ottaviani, Augusto Poropat, Roberto Di Lenarda, Matteo Biasotto and Sergio Crovella

Volume 25, Issue 4, 2018

Page: [326 - 329] Pages: 4

DOI: 10.2174/0929866525666180221123249

Price: $65

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Abstract

Introduction: Laser Therapy (LT) has been employed for the treatment of Oral Mucositis (OM) due to its anti-inflammatory, analgesic and bio-stimulatory effects.

Objective: This pilot study investigated the effect of LT on the expression of DEFB1, DEFB4, DEFB103 genes encoding for the human β-defensins 1, 2 and 3.

Materials and Method: TR146 epithelial cell line, used to mimic oral mucosa, was irradiated with different LT protocols. β-defensins gene expression was evaluated using TaqMan probes on Real- Time PCR platform.

Results and Conclusion: In this cellular model LT decreased mRNA defensins' expression 30 minutes after irradiation but not 24 hours later, suggesting that LT is able to influence β -defensins production immediately after treatment, while its efficacy decreases over time.

Keywords: Innate immunity, β-defensins, gene expression, laser therapy, oral mucositis, real time PCR.

Graphical Abstract

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