Bis-coumarin Derivatives and Their Biological Activities

Title:Bis-coumarin Derivatives and Their Biological Activities

Volume: 18 Issue: 2

Author(s): Qing-Cheng Ren, Chuan Gao, Zhi Xu, Lian-Shun Feng, Ming-Liang Liu*, Xiang Wu*Feng Zhao*

Affiliation:

• State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, Hubei,China

• WuXi AppTec (Wuhan), Hubei,China

• WuXi AppTec (Wuhan), Hubei,China

Keywords: Bis-coumarin, anti-bacterial, antitumor, antiviral, hybrid compounds, structure-activity relationships.

Abstract: Bis-coumarins have caused great interests in the recent years. These compounds exhibit diverse biological activities which are ascribed to their ability to exert noncovalent interactions with the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved for therapeutic purposes in clinical practice. Encouraged by the above facts, numerous biscoumarin derivatives have been synthesized and screened for their biological activities, and many of them showed promising potency. This review is focused on the biological potential of bis-coumarin derivatives with particular mention of those exhibiting antibacterial, anticoagulant, antiinflammatory, antiviral, anti-parasite and antitumor activities, and their structure-activity relationships are also discussed.

Cite this article as:

Ren Qing-Cheng, Gao Chuan , Xu Zhi , Feng Lian-Shun , Liu Ming-Liang *, Wu Xiang*, Zhao Feng *, Bis-coumarin Derivatives and Their Biological Activities, Current Topics in Medicinal Chemistry 2018; 18 (2) . https://dx.doi.org/10.2174/1568026618666180221114515