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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Bis-coumarin Derivatives and Their Biological Activities

Author(s): Qing-Cheng Ren, Chuan Gao, Zhi Xu, Lian-Shun Feng, Ming-Liang Liu*, Xiang Wu* and Feng Zhao*

Volume 18, Issue 2, 2018

Page: [101 - 113] Pages: 13

DOI: 10.2174/1568026618666180221114515

Price: $65


Bis-coumarins have caused great interests in the recent years. These compounds exhibit diverse biological activities which are ascribed to their ability to exert noncovalent interactions with the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved for therapeutic purposes in clinical practice. Encouraged by the above facts, numerous biscoumarin derivatives have been synthesized and screened for their biological activities, and many of them showed promising potency. This review is focused on the biological potential of bis-coumarin derivatives with particular mention of those exhibiting antibacterial, anticoagulant, antiinflammatory, antiviral, anti-parasite and antitumor activities, and their structure-activity relationships are also discussed.

Keywords: Bis-coumarin, anti-bacterial, antitumor, antiviral, hybrid compounds, structure-activity relationships.

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