Abstract
Cardiovascular disease is the most common cause of death in todays society. Heart transplantation is the only available treatment for patients suffering from end-stage congestive heart failure (CHF). Causes underlying the development of CHF are still unknown, but it has been suggested that proinflammatory cytokines play an important role. In the context of transplantation, proinflammatory T-helper 1 cytokines like TNF-α and IL-2 that mediate the cellular immune response are believed to be involved in acute graft rejection. On the other hand, Th2 cytokines, like IL-4, IL-6 and IL-10, induce tolerance, by down-regulating the Th1 response and cytokine production. Cytokine release by macrophages, lymphocytes and other cell types in the microenvironment of the graft, especially the balance between Th1 and Th2, is thought to be critical for the development of acute rejection. Production of cytokines has been shown to be under genetic control of single nucleotide polymorphisms (SNP) in mainly the promoter regions of cytokine genes. Genotypes of these SNP were shown to control the differential production of these cytokines, leading to a wide variety of cytokine patterns among individuals. Since levels of these cytokines affect the Th1 / Th2 balance, genotypes may be related to acute allograft rejection. Many studies have shown an association between cytokine gene polymorphisms and the development of several infections, allergies and autoimmune diseases. Also, associations between SNP in different cytokine genes and transplant rejection have been extensively studied. In our lab, SNP in the genes of TNF-α, TGF-β, IL- 4 and IL-10 were studied in a panel of 70 cardiac transplant patients and 61 of their donors. These data are discussed in the context of literature data.
Keywords: cytokine gene, gene polymorphism, heart transplantation, single nucleotide polymorphism, snp
Current Genomics
Title: Cytokine Gene Polymorphism in Heart Transplantation: A Review
Volume: 4 Issue: 3
Author(s): F. J. Bijlsma, A. H. Bruggink, F. H.J. Gmelig-Meyling and R.A. de Weger
Affiliation:
Keywords: cytokine gene, gene polymorphism, heart transplantation, single nucleotide polymorphism, snp
Abstract: Cardiovascular disease is the most common cause of death in todays society. Heart transplantation is the only available treatment for patients suffering from end-stage congestive heart failure (CHF). Causes underlying the development of CHF are still unknown, but it has been suggested that proinflammatory cytokines play an important role. In the context of transplantation, proinflammatory T-helper 1 cytokines like TNF-α and IL-2 that mediate the cellular immune response are believed to be involved in acute graft rejection. On the other hand, Th2 cytokines, like IL-4, IL-6 and IL-10, induce tolerance, by down-regulating the Th1 response and cytokine production. Cytokine release by macrophages, lymphocytes and other cell types in the microenvironment of the graft, especially the balance between Th1 and Th2, is thought to be critical for the development of acute rejection. Production of cytokines has been shown to be under genetic control of single nucleotide polymorphisms (SNP) in mainly the promoter regions of cytokine genes. Genotypes of these SNP were shown to control the differential production of these cytokines, leading to a wide variety of cytokine patterns among individuals. Since levels of these cytokines affect the Th1 / Th2 balance, genotypes may be related to acute allograft rejection. Many studies have shown an association between cytokine gene polymorphisms and the development of several infections, allergies and autoimmune diseases. Also, associations between SNP in different cytokine genes and transplant rejection have been extensively studied. In our lab, SNP in the genes of TNF-α, TGF-β, IL- 4 and IL-10 were studied in a panel of 70 cardiac transplant patients and 61 of their donors. These data are discussed in the context of literature data.
Export Options
About this article
Cite this article as:
Bijlsma J. F., Bruggink H. A., Gmelig-Meyling H.J. F. and Weger de R.A., Cytokine Gene Polymorphism in Heart Transplantation: A Review, Current Genomics 2003; 4 (3) . https://dx.doi.org/10.2174/1389202033490411
DOI https://dx.doi.org/10.2174/1389202033490411 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Phosphodiesterase 4 Inhibitors in Inflammatory Bowel Disease: A Comprehensive Review
Current Pharmaceutical Design Use of Medication in Coronary Imaging by CT
Current Medical Imaging Heart Valve Lesions In The Antiphospholipid Syndrome
Current Rheumatology Reviews Current Problems, New Opportunities and Future Directions of Antiplatelet Therapy - Increasing Role of Novel Antiplatelet Agents in Cardiovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Beneficial Effects of Statins on Endothelial Dysfunction and Vascular Stiffness
Current Vascular Pharmacology Effect of Ouabain on the Immune System
Current Hypertension Reviews Fluoride Effects: The Two Faces of Janus
Current Medicinal Chemistry Neonatal Ultrasound in Transport
Current Pediatric Reviews The Role of microRNAs in the Initiation and Progression of Stable Atheromatous Plaque
Current Pharmaceutical Design Activin Receptor-Like Kinase 1: a Novel Anti-angiogenesis Target from TGF-β Family
Mini-Reviews in Medicinal Chemistry Diuretic-Associated Electrolyte Disorders in the Elderly: Risk Factors, Impact, Management and Prevention
Current Drug Safety Metalloprotein Inhibitors for the Treatment of Human Diseases
Current Topics in Medicinal Chemistry Relationships of Beta2- and Beta3--Adrenoceptor Polymorphisms with Obesity, Hypertension and Metabolic Syndrome
Current Hypertension Reviews Integrated Nutritional Supports for Diabetic Patients During COVID-19 Infection: A Comprehensive Review
Current Diabetes Reviews Sexual Dysfunction, Cardiovascular Risk and Effects of Pharmacotherapy
Current Vascular Pharmacology The Influence of Fatty Acids on Metoprolol - Human Serum Albumin Interaction in Low Affinity Binding Sites: A Multifactorial NMR Approach
Protein & Peptide Letters Exploring New CGRP Family Peptides and their Receptors in Vertebrates
Current Protein & Peptide Science Plasma Glucose Concentrations and Cardiac Hypertrophy in Essential Hypertension
Current Hypertension Reviews Nanomaterial Based Approaches for the Diagnosis and Therapy of Cardiovascular Diseases
Current Pharmaceutical Design Meta-Analysis of Anticancer Drug Structures - Significance of Their Polar Allylic Moieties
Anti-Cancer Agents in Medicinal Chemistry