摘要
黄酮类化合物是几乎所有陆地植物中都存在的植物化学物质,因此,它存在于以植物为基础的食物中,因此被人类通过饮食所消耗。最近的证据表明几个FlavONIC对老年痴呆症和阿尔茨海默病有积极的治疗作用,逆转了与年龄相关的神经认知能力的下降.在这篇综述中,我们提供了自然和合成类黄酮,描述它们的理化性质,特别是它们的氧化还原性质和稳定性,并对它们的生物活性和结构进行了广泛的综述。-神经退行性疾病领域的活动关系。此外,还将有一节专门讨论生物活性衍生物的合成策略。这个信息w这对于设计和开发能够改善大脑功能的新药至关重要。
关键词: 阿尔茨海默病、类黄酮、神经退行性疾病、抗氧化剂、合成方法、类似物。
Current Medicinal Chemistry
Title:Flavonoids in the Treatment of Alzheimer’s and Other Neurodegenerative Diseases
Volume: 25 Issue: 27
关键词: 阿尔茨海默病、类黄酮、神经退行性疾病、抗氧化剂、合成方法、类似物。
摘要: Flavonoids are phytochemicals present in almost all terrestrial plants and, as a consequence, in plant-based foods, and thus consumed by humans through diet. Recent evidences suggest that several flavonoids have positive effects against dementia and Alzheimer’s disease, reversing age-related declines in neurocognitive performances. In this review, we provide a general classification of natural and synthetic flavonoids, a description of their physico-chemical properties, in particular their redox properties and stability, and an extensive overview about their biological activities and structure-activity relationship in the field of neurodegenerative diseases. In addition, a section will be dedicated to the synthetic strategies for the preparation of bioactive derivatives. This information will be essential for the design and development of new drugs that can improve brain functions.
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Cite this article as:
Flavonoids in the Treatment of Alzheimer’s and Other Neurodegenerative Diseases, Current Medicinal Chemistry 2018; 25 (27) . https://dx.doi.org/10.2174/0929867325666180209132125
DOI https://dx.doi.org/10.2174/0929867325666180209132125 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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