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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Advances in the Oxidation of Biginelli Compounds

Author(s): Mousa Soleymani*

Volume 22, Issue 9, 2018

Page: [890 - 911] Pages: 22

DOI: 10.2174/1385272822666180129144507

Price: $65


Biginelli compounds are one of the most important heterocyclic systems that play an important role in medicinal chemistry. It has been proved that the biological activities of these compounds are dependent on the absolute configuration of the C4 atom of the heterocyclic ring, and thus the oxidative dehydrogenation reaction can affect their biological and pharmaceutical activities. In this review, the oxidation methods of various Biginelli compounds have been summarized with a focus on the conditions of the reactions, the proposed mechanisms, and the effect of the substituents on the reaction.

Keywords: Biginelli reaction, oxidation, dehydrogenation, 2-oxo-1, 2, 3, 4-tetrahydropyrimidine, 2-thioxo-1, 2, 3, 4-tetrahydropyrimidine, dihydropyrimidinone, pyrimidinone, pyrimidine.

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