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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry


ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Review Article

Therapeutic Potential of N-heterocyclic Analogs as Anti-inflammatory Agents

Author(s): Ashwani K. Dhingra*, Bhawna Chopra, Jagdeep S. Dua and Deo N. Prasad

Volume 16, Issue 3, 2017

Page: [136 - 152] Pages: 17

DOI: 10.2174/1871523017666180126150901

Price: $65


Background: Various mediators and anti-inflammatory drugs were used since from a long time but it is still a challenge for the medicinal chemists to treat or reduce the symptoms of inflammatory diseases. Most of the clinically used anti-inflammatory drugs such as NSAIDs, Coxibs and GCs are allied with considerable toxicity.

Objective: The search of novel anti-inflammatory agent is not an ending process. Although the drug treatment has been improved steadily but yet, it is still there is a need to develop more potent therapeutic agents.

Method: Reported literature survey has been studied to summarize the nitrogen containing moieties which were utilized as potential therapeutic agents.

Results: A variety of N-heterocyclic analogs are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal and anti-HIV. However, numerous approaches were used to overcome the toxicity level such as co-administration with suitable agent/substance which provides protection against toxicity as well to synthesise new potent and safe anti-inflammatory drug.

Conclusion: The present review summarizes the synthetic methodology and therapeutic potential of some N-heterocyclic analogs as potent anti-inflammatory agents.

Keywords: Imidazole, inflammation, NSAIDs, pyrazoles, pyrimidine, quinazoline.

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