Abstract
Gene therapy has been receiving widespread attention due to its unique advantage in regulating the expression of specific target genes. In the field of cancer gene therapy, modulation of gene expression has been shown to decrease oncogenic factors in cancer cells or increase immune responses against cancer. Due to the macromolecular size and highly negative physicochemical features of plasmid DNA, efficient delivery systems are an essential ingredient for successful gene therapy. To date, a variety of nanostructures and materials have been studied as nonviral gene delivery systems. In this review, we will cover nonviral delivery strategies for cancer gene therapy, with a focus on target cancer genes and delivery materials. Moreover, we will address current challenges and perspectives for nonviral delivery-based cancer gene therapeutics.
Keywords: Cancer gene therapy, Nonviral gene therapy, Nonviral delivery, Target cancer gene, Macromolecular, DNA.
Call for Papers in Thematic Issues
Epigenetic Mechanisms in Human Diseases and Gene Therapy
Epigenetic mechanisms including DNA methylation, histone post-translational modifications, non-coding RNAs and chromatin remodeling play crucial roles in gene expression. Aberrant epigenetic changes are often correlated with human diseases and metabolic disorders. Since gene expression can be activated/inactivated by reversible epigenetic mechanisms, increasing studies have been focused on epigenetic regulation in ...read more
Gene- and Cell-Based Therapeutics in Prostate Cancer: Emerging Opportunities and Challenges
Prostate cancer is the second most frequently diagnosed cancer in men worldwide and remains a leading cause of cancer mortality. While advances in androgen receptor–targeted therapies, radioligand treatment, and immunotherapy have improved outcomes, resistance and disease progression continue to present major challenges. Recent breakthroughs in gene and cell therapies — ...read more
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers
Programmed cell death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
The Now and Future of Gene Transfer Technologies
Gene and cell therapies rely on a gene delivery system which is safe and effective. Both viral and non-viral vector systems are available with specific pros and cons. The choice of a vector system is largely dependent on the application which is a balance between target tissue/disease and safety, efficacy ...read more
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