摘要
背景:血管危险因素和白质损害对轻度认知功能障碍(MCI)进展至痴呆症的影响的证据并不确定。 目的:该研究旨在从全球角度分析这些因素对MCI痴呆进展的影响。 方法:我们的研究包括105例MCI患者。 结果:平均随访3.09年(范围2-3.79)后,47例(44.76%)进展为痴呆:混合性痴呆32例(30.8%),可能性AD 13例(12.5%),2例(1.9%)血管性痴呆。总胆固醇水平(OR:1.015 [1.003-1.028])和LDL胆固醇水平(OR:1.018 [1.004-1.032])增加了患痴呆的风险。半胱氨酸蛋白酶抑制剂C是抵抗痴呆进展的保护因子(OR:0.119 [0.015-0.944],p = 0.044)。在第二年的随访期间,皮质下白质高信号的存在增加了痴呆进展的风险(OR:5.854 [1.008-33.846])。在第二年随访期间,皮质下和脑室周围白质高信号也与进展为痴呆的风险增加有关(OR分别为3.130 [1.098-8.922]和OR:3.561 [1.227-10.334])。沉默梗塞也是如此(OR:4.308 [1.480-12.500])。 结论:高比例的患者发展为痴呆。发现总胆固醇,低密度脂蛋白胆固醇和白质高信号与MCI进展为痴呆有关。相反,半胱氨酸蛋白酶抑制剂C被证明是防止痴呆进展的保护因子。
关键词: 轻度认知障碍,痴呆,白质高强度,血管危险因素,阿尔茨海默病,胆固醇。
Current Alzheimer Research
Title:Vascular Risk Factors and Lesions of Vascular Nature in Magnetic Resonance as Predictors of Progression to Dementia in Patients with Mild Cognitive Impairment
Volume: 15 Issue: 7
关键词: 轻度认知障碍,痴呆,白质高强度,血管危险因素,阿尔茨海默病,胆固醇。
摘要: Background: Evidence of the effect of vascular risk factors and white matter lesions on the progression of mild cognitive impairment (MCI) to dementia is not conclusive.
Objective: The study aimed to analyze the impact of these factors on MCI progression to dementia from a global perspective.
Methods: Our study included a population of 105 patients with MCI.
Results: After a mean follow-up period of 3.09 years (range, 2-3.79), 47 patients (44.76%) progressed to dementia: 32 (30.8%) to mixed dementia, 13 (12.5%) to probable AD, and 2 (1.9%) to vascular dementia. Total cholesterol levels (OR: 1.015 [1.003-1.028]) and LDL cholesterol levels (OR: 1.018 [1.004-1.032]) increased the risk of progression to dementia. Cystatin C was a protective factor against progression to dementia (OR: 0.119 [0.015-0.944], p = 0.044). During the second year of follow-up, the presence of subcortical white matter hyperintensities increased the risk of progression to dementia (OR: 5.854 [1.008- 33.846]). Subcortical and periventricular white matter hyperintensities were also associated with an increased risk of progression to dementia during the second year of follow-up (OR: 3.130 [1.098-8.922] and OR: 3.561 [1.227-10.334], respectively). The same was true for silent infarcts (OR: 4.308 [1.480- 12.500]).
Conclusion: A high percentage of patients progressed to dementia. Total cholesterol, LDL cholesterol, and white matter hyperintensities were found to be associated with MCI progression to dementia. In contrast, cystatin C was shown to be a protective factor against progression to dementia.
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Cite this article as:
Vascular Risk Factors and Lesions of Vascular Nature in Magnetic Resonance as Predictors of Progression to Dementia in Patients with Mild Cognitive Impairment, Current Alzheimer Research 2018; 15 (7) . https://dx.doi.org/10.2174/1567205015666180119100840
DOI https://dx.doi.org/10.2174/1567205015666180119100840 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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